RT journal article
T1 Arm-cranking exercise reduced oxidative damage in adults with chronic spinal cord injury.
A1 Ordóñez Muñoz, Francisco Javier
A1 Rosety Rodríguez, Miguel Ángel
A1 Camacho, Alejandra
A1 Rosety Rodríguez, Ignacio
A1 Díaz Ordóñez, Antonio Jesús
A1 Fornieles, Gabriel
A1 Bernardi, Marco
A1 Rosety Rodríguez, Manuel
A2 Anatomía y Embriología Humana
A2 Didáctica de la Educación FísicaPlástica y Musical
A2 Medicina
K1 BMI
K1 Exercise
K1 FES
K1 GPX
K1 Oxidative stress
K1 Rehabilitation
K1 SCI
K1 Spinal cord injuries
K1 VO(2)max
K1 anthropometric index
K1 body mass index
K1 functional electrical stimulation
K1 glutathione peroxidase
K1 maximum oxygen consumption
K1 spinal cord injury
AB Objective: To assess the effect of a 12-week arm-cranking exercise program on reducing oxidative damage in untrained adults with chronic spinal cord injury (SCI).Design: Randomized controlled trial.Setting: Community-based supervised intervention.Participants: Male adults with complete SCI at or below the fifth thoracic level (T5) (N=17) volunteered for this study. Participants were randomly allocated to the intervention (n=9) or control (n=8) group using a concealed method.Intervention: A 12-week arm-cranking exercise program, 3 sessions/wk, consisting of warming-up (10-15min) followed by a main part in arm-crank (20-30min [increasing 2min and 30s every 3wk]) at a moderate work intensity of 50% to 65% of the heart rate reserve (starting at 50% and increasing 5% every 3 weeks) and by a cooling-down period (5-10min).Main outcome measures: Plasmatic levels of total antioxidant status as well as erythrocyte glutathione peroxidase activity were measured. Lipid and protein oxidation were determined as malondialdehyde and carbonyl group levels, respectively. Furthermore, physical fitness and body composition were assessed.Results: When compared with baseline results, maximum oxygen consumption was significantly increased (P=.031), suggesting an improvement in physical fitness in the intervention group. Regarding the antioxidant defense system, it was found that both total antioxidant status (P=.014) and erythrocyte glutathione peroxidase activity (P=.027) were significantly increased at the end of the training program. As a consequence, plasmatic levels of malondialdehyde (P=.008) and carbonyl groups (P=.022) were significantly reduced.Conclusion: A 12-week arm-cranking exercise program improved the antioxidant defense system in adults with chronic SCI, which may finally attenuate both lipid and protein oxidation in this population.
SN 1532-821X
YR 2013
FD 2013-12-01
LK http://hdl.handle.net/10498/34657
UL http://hdl.handle.net/10498/34657
LA eng
NO Articulo original derivado de proyecto obtenido en convocatoria pública competitiva.
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026