RT journal article
T1 Anti-inflammatory effect of exercise, via reduced leptin levels, in obese women with Down syndrome. I
A1 Ordóñez Muñoz, Francisco Javier
A1 Fornieles González, Gabriel
A1 Camacho, Alejandra
A1 Rosety Rodríguez, Miguel Ángel
A1 Rosety Rodríguez, Ignacio
A1 Díaz Ordóñez, Antonio Jesús
A1 Rosety Rodríguez, Manuel
A2 Anatomía y Embriología Humana
A2 Didáctica de la Educación FísicaPlástica y Musical
A2 Medicina
K1 Down syndrome
K1 exercise
K1 intellectual disability
K1 low-grade inflammation
K1 women
AB Recent studies have reported that obese young people with Down syndrome suffer from low-grade systemic inflammation. Whereas this condition may be improved in the general population by regular exercise, the problem has received no attention in the case of people with intellectual disability. Therefore, the authors' aim was to assess the influence of aerobic training on plasma adipokines in obese women with Down syndrome. Twenty obese young women with Down syndrome volunteered for this study, 11 of whom were randomly assigned to a 10-wk aerobic-training program. They attended 3 sessions/wk, which consisted of warm-up exercises followed by the main activity on a treadmill (30-40 min) at a work intensity of 55-65% of peak heart rate and ended with a cooling-down period. The control group included 9 women with Down syndrome matched for age, sex, and body-mass index. Fat-mass percentage and distribution were measured, and plasma adipokine levels (leptin and adiponectin) were assessed. In addition, each participant performed a maximal graded continuous treadmill exercise test. These parameters were assessed pre- and postintervention. Aerobic training produced a significant increase in participants' maximal oxygen uptake (20.2 ± 5.8 vs.23.7 ± 6.3 ml · kg-1 · min-1; p < .001), and plasma leptin levels were significantly reduced in the intervention group (54.2 ± 6.7 vs.45.7 ± 6.1 ng/ml; p = .026). Further significant correlations between plasma leptin and indices of obesity were found. In contrast, no significant changes were found in adiponectin levels (p > .05). None of the tested parameters changed in the control group. In conclusion, a 10-week training program reduced leptin levels in obese young women with Down syndrome.
PB HUMAN KINETICS
SN 1526-484X
YR 2013
FD 2013-06-01
LK http://hdl.handle.net/10498/34658
UL http://hdl.handle.net/10498/34658
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026