RT journal article
T1 Accumbens and amygdala in taste recognition memory: The role of d1 dopamine receptors
A1 Grau-Perales, Alejandro
A1 Alejandro Navarro, Expósito
A1 Gómez Chacón, Beatriz
A1 Morón, Ignacio
A1 Gallo, Milagros
A2 Didáctica
A2 Psicología
K1 Accumbens
K1 Amygdala
K1 Attenuation of neophobia
K1 D1DR
K1 Dopamine
K1 Neophobia
K1 Taste
AB The attenuation of taste neophobia (AN) is a good model for studying the structural and neurochemical mechanisms of the emotional component of memory because taste recognition memory exhibits the unique feature of being necessarily linked to hedonic properties. Whilst novel tastes elicit cautious neophobic responses, taste exposures which are not followed by aversive consequences attenuate neophobia as the taste becomes safe and palatable. Given the involvement of the nucleus accumbens in reward and of the amygdala in emotional memories, we applied c-Fos immunohistochemistry as an index of neural activity in Wistar rats that were exposed to a vinegar solution for one, two or six days. An inverse pattern of accumbens nucleus vs amygdala activity was found on the second exposure day on which AN occurred. The number of c-Fos positive cells in the nucleus accumbens shell increased whilst the number of c-Fos positive cells in the basolateral amygdala decreased. Further analyses revealed a positive correlation between AN and the number of c-Fos positive cells in the accumbens shell but a negative correlation in the basolateral amygdala. Furthermore the accumbens-amygdala interplay relevant for AN seems to be mediated by dopamine D1 receptors (D1DR). The injection of SCH23390 (D1DR antagonist) in both the accumbens shell and the basolateral amygdala on the second taste exposure resulted in selectively impaired AN but had opposite long term effects. This finding supports the relevance of a dopaminergic network mediated by D1DRs in the nucleus accumbens shell and basolateral amygdala which is critical for adding the emotional component during the formation of taste memory.
PB Elsevier
SN 1074-7427
YR 2020
FD 2020
LK http://hdl.handle.net/10498/34694
UL http://hdl.handle.net/10498/34694
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 14-nov-2026