RT journal article
T1 Resistance circuit training reduced inflammatory cytokines in a cohort of male adults with Down syndrome.
A1 Rosety Rodríguez, Manuel
A1 Camacho, Alejandra
A1 Rosety Rodríguez, Ignacio
A1 Fornieles González, Gabriel
A1 Díaz Ordóñez, Antonio Jesús
A1 Rosety Rodríguez, Miguel Ángel
A1 Ordóñez Muñoz, Francisco Javier
A2 Anatomía y Embriología Humana
A2 Didáctica de la Educación FísicaPlástica y Musical
A2 Medicina
K1 Down syndrome
K1 resistance training
K1 intellectual disability
K1 low-grade inflammation
AB Background: It is widely accepted that muscle strength plays a key role on functional tasks of daily living and employability in individuals with Down syndrome (DS). Recent studies have also reported resistance training may improve chronic inflammation in other clinical situations. This is the first study conducted to determine the effect of resistance circuit training on low-grade systemic inflammation in adults with DS.Material/methods: A total of 40 young male adults with DS were recruited for the trial through different community support groups for people with intellectual disabilities and their families. They had medical approval for physical activity participation. Twenty-four were randomly assigned to perform resistance circuit training with 6 stations, 3 days per week for 12 weeks. Exercise intensity was based on function of the 8RM assessments. The control group included 16 age-, sex-, and BMI-matched adults with Down syndrome. Plasma levels of leptin, adiponectin, and TNF-a were assessed by commercial ELISA kits. C-reactive protein (CRP) was assessed by nephelometry. Body composition was also determined, measuring fat-free mass percentage and waist circumference (WC). This protocol was approved by our Institutional Ethics Committee.Results: Plasma levels of leptin, TNF-a, and IL-6 were significantly decreased after the completion of the training program, as were fat-free mass and WC. No sports-related injuries or withdrawals from the program were reported during the entire study period. No changes were observed in the control group.Conclusions: Resistance circuit training improved low-grade systemic inflammation in male sedentary adults with DS.
SN 1234-1010
YR 2013
FD 2013-11-07
LK http://hdl.handle.net/10498/34710
UL http://hdl.handle.net/10498/34710
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026