RT journal article
T1 Low-grade systemic inflammation and leptin levels were improved by arm cranking exercise in adults with chronic spinal cord injury.
A1 Rosety Rodríguez, Manuel
A1 Camacho, Alejandra
A1 Rosety Rodríguez, Ignacio
A1 Fornieles González, Gabriel
A1 Rosety Rodríguez, Miguel Ángel
A1 Díaz Ordóñez, Antonio Jesús
A1 Bernardi, Marco
A1 Ordóñez Muñoz, Francisco Javier
A2 Anatomía y Embriología Humana
A2 Didáctica de la Educación FísicaPlástica y Musical
A2 Medicina
K1 AI
K1 BMI
K1 Exercise
K1 IL-6
K1 PAI-1
K1 Rehabilitation
K1 SCI
K1 Spinal cord injuries
K1 TNF-α
K1 WC
K1 anthropometric index
K1 body mass index
K1 interleukin-6
K1 maximum oxygen consumption
K1 o(2)max
K1 plasminogen activator inhibitor-1
K1 spinal cord injury
K1 tumor necrosis factor-alpha
K1 waist circumference
AB Objective: To ascertain the effect of arm cranking exercise on improving plasma levels of inflammatory cytokines and adipokines in untrained adults with chronic spinal cord injury (SCI).Design: Longitudinal study.Setting: Community-based supervised intervention.Participants: Men (N=17) with complete SCI at or below T5 volunteered for this study. Participants were randomly allocated to the intervention (n=9) or control group (n=8) using a concealed method.Intervention: A 12-week arm cranking exercise program of 3 sessions per week consisted of warm-up (10-15min), arm crank (20-30min; increasing 2min and 30s every 3wk) at a moderate work intensity of 50% to 65% of heart rate reserve (starting at 50% and increasing 5% every 3wk), and cool-down (5-10min).Main outcome measures: Plasma levels of leptin, adiponectin, plasminogen activator inhibitor-1, tumor necrosis factor-alpha, and interleukin-6 were determined. Furthermore, physical fitness (maximum oxygen consumption [V˙O2max]) and body composition (anthropometric index, waist circumference, and body mass index) were also assessed.Results: Plasma levels of leptin, tumor necrosis factor-alpha, and interleukin-6 were significantly decreased after the completion of the training program. Similarly, the anthropometric index and waist circumference were diminished too. A moderate correlation was found between leptin and the anthropometric index. Finally, V˙O2max was significantly increased, suggesting an improvement of physical fitness in the intervention group. No changes were found in the control group.Conclusions: Arm cranking exercise improved low-grade systemic inflammation by decreasing plasma levels of inflammatory cytokines. Furthermore, it also reduced plasma leptin levels. Long-term, well-conducted studies are still required to determine whether these changes may improve clinical outcomes of adults with chronic SCI.
SN 0003-9993
YR 2014
FD 2014-02-01
LK http://hdl.handle.net/10498/34712
UL http://hdl.handle.net/10498/34712
LA eng
NO Artículo original derivado de un proyecto obtenido en convocatoria pública competitiva. La principal conclusión fue que un programa de intervención basado en ejercicio con manivelas consiguió reducir los niveles de citokinas proinflamatorias en personas con lesión medular crónica.
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026