RT journal article
T1 Aerobic training improved low-grade inflammation in obese women with intellectual disability.
A1 Ordóñez Muñoz, Francisco Javier
A1 Rosety Rodríguez, Miguel Ángel
A1 Camacho, Alejandra
A1 Rosety Rodríguez, Ignacio
A1 Díaz Ordóñez, Antonio Jesús
A1 Fornieles González, Gabriel
A1 García Gómez, Natalia
A1 Rosety Rodríguez, Manuel
A2 Anatomía y Embriología Humana
A2 Didáctica de la Educación FísicaPlástica y Musical
A2 Medicina
K1 Down syndrome
K1 exercise
K1 intellectual disability
K1 low-grade inflammation
K1 women
AB Background: Obesity is a major health problem in people with intellectual disabilities. It is also widely accepted that low-grade systemic inflammation associated to obesity plays a key role in the pathogenic mechanism of several disorders. Fortunately, physical activity has shown to improve inflammation in people with metabolic syndrome and type 2 diabetes. Accordingly, we assessed the influence of aerobic training on pro-inflammatory cytokines and acute phase proteins in women with Down syndrome.Methods: To achieve this outcome, 20 premenopausal obese young women with Down syndrome volunteered for this study. Eleven were randomly assigned to the intervention group and performed a 10-week aerobic training programme, three sessions per week, consisting of a warm-up then a 30- to 40-min treadmill exercise at a work intensity of 55-65% of peak heart rate followed by a cooling-down period. The control group included nine age-, sex- and body mass index-matched women with Down syndrome. Fat mass percentage and fat distribution were measured. Plasmatic levels of tumour necrosis factor (TNF)-α, interleukin (IL)-6 and fibrinogen were assessed by commercial enzyme-linked immunosorbent assay kits. C-reactive protein (CRP) was assessed by nephelometry.Results: Plasmatic levels of TNF-α (11.7 ± 1.6 vs. 9.2 ± 1.3 pg/ml; P = 0.022), IL-6 (8.2 ± 1.1 vs. 6.1 ± 0.9 pg/ml; P = 0.014) and high sensitive CRP (0.62 ± 0.11 vs. 0.53 ± 0.09 mg/dl; P = 0.009) were significantly reduced in the intervention group. Further, significant correlations between plasmatic and anthropometric parameters were found.Conclusion: A 10-week training programme reduced pro-inflammatory cytokines and acute phase proteins in obese young women with Down syndrome. Long-term, well-conducted studies are still required to determine whether correction of this low-grade inflammation improves clinical outcomes of women with trisomy 21.
PB WILEY ONLINE LIBRARY
SN 0964-2633
YR 2014
FD 2014-06-01
LK http://hdl.handle.net/10498/34713
UL http://hdl.handle.net/10498/34713
LA eng
NO Los resultados de este trabajo derivaron de un proyecto obtenido en convocatoria pública competitiva.
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026