RT journal article
T1 Cystoseira usneoides: A Brown Alga Rich in Antioxidant and Antiinflammatory Meroditerpenoids
A1 Reyes Jiménez, Carolina de los
A1 Ortega Agüera, María Jesús
A1 Zbakh, Hanna
A1 Motilva, Virginia
A1 Zubía Mendoza, Eva
A2 Química Orgánica
AB Twelve new meroditerpenoids, 1−12, along with eight known compounds, have been isolated from the brown alga Cystoseira usneoides collected off the coast of Tarifa (Spain). The structures of the new metabolites have been established by spectroscopic techniques. All of the new compounds consist of a toluhydroquinone-derived nucleus linked to a regular diterpenoid moiety, which can be either acyclic or contain an ether ring. Most structural diversity arises from the presence of different oxygenated functionalities and unsaturations along the two terminal isoprenoid units of the diterpene backbone. Twelve of the isolated meroditerpenes have been tested in antioxidant assays. All of them have shown radical scavenging activity. The most active compounds were cystodiones G (1) and H (2), 11-hydroxyamentadione (15), and amentadione (16), which exhibited antioxidant activities in the range 77-87% that of the Trolox standard. In anti-inflammatory assays, cystodiones G (1) and M (6), cystone C (9), 11-hydroxyamentadione (15), and amentadione (16) showed significant activity as inhibitors of the production of the proinflammatory cytokine TNF-α in LPS-stimulated THP-1 human macrophages.
PB ACS
SN 1520-6025
YR 2016
FD 2016-02-09
LK http://hdl.handle.net/10498/34729
UL http://hdl.handle.net/10498/34729
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026