RT journal article
T1 Cellular and molecular mechanisms triggered by Deep Brain Stimulation in depression: A preclinical and clinical approach.
A1 Torres Sánchez, Sonia
A1 Perez-Caballero, Laura
A1 Berrocoso Domínguez, Esther María
A2 Neurociencias
A2 Psicología
K1 BDNF
K1 Deep Brain Stimulation
K1 Glutamate
K1 Major Depressive Disorder
K1 Monoamines
K1 Neurotrophins
K1 cfos
AB Deep Brain Stimulation (DBS) was originally developed as a therapeutic approach to manage movement disorders, in particular Parkinson's Disease. However, DBS also seems to be an effective treatment against refractory depression when patients fail to respond satisfactorily to conventional therapies. Thus, DBS targeting specific brain areas can produce an antidepressant response that improves depressive symptomatology, these areas including the subcallosal cingulate region, nucleus accumbens, ventral capsule/ventral striatum, medial forebrain bundle, the inferior thalamic peduncle and lateral habenula. Although the efficacy and safety of this therapy has been demonstrated in some clinical trials and preclinical studies, the intrinsic mechanisms underlying its antidepressant effect remain poorly understood. This review aims to provide a comprehensive overview of DBS, focusing on the molecular and cellular changes reported after its use that could shed light on the mechanisms underpinning its antidepressant effect. Several potential mechanisms of action of DBS are considered, including monoaminergic and glutamatergic neurotransmission, neurotrophic and neuroinflammatory mechanisms, as well as potential effects on certain intracellular signaling pathways. Although future studies will be necessary to determine the key molecular events underlying the antidepressant effect of DBS, the findings presented provide an insight into some of its possible modes of action.
PB Elsevier
SN 0278-5846
YR 2017
FD 2017-02
LK http://hdl.handle.net/10498/34780
UL http://hdl.handle.net/10498/34780
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 09-nov-2026