RT journal article
T1 Central Proliferation and Neurogenesis Is Impaired in Type 2 Diabetes and Prediabetes Animal Models
A1 Ramos-Rodríguez, Juan José
A1 Molina-Gil, Sara
A1 Ortiz-Barajas, Oscar
A1 Jiménez Palomares, Margarita
A1 Perdomo, Germán
A1 Cozar-Castellano, Irene
A1 Lechuga Sancho, Alfonso María
A1 García Alloza, Mónica
A2 BiomedicinaBiotecnología y Salud Pública
K1 HIGH-FAT DIET
K1 ALZHEIMERS-DISEASE
K1 INSULIN-RESISTANCE
K1 HIPPOCAMPAL NEUROGENESIS
K1 COGNITIVE IMPAIRMENT
K1 DEFECTIVE INSULIN
K1 MOUSE MODEL
K1 BRAIN
K1 DEMENTIA
K1 DEFICITS
AB Type 2 diabetes (T2D) is an important risk factor to suffer dementia, including Alzheimer's disease (AD), and some neuropathological features observed in dementia could be mediated by T2D metabolic alterations. Since brain atrophy and impaired neurogenesis have been observed both T2D and AD we analyzed central nervous system (CNS) morphological alterations in the db/db mice (leptin receptor KO mice), as a model of long-term insulin resistance and T2D, and in C57Bl6 mice fed with high fat diet (HFD), as a model of diet induced insulin resistance and prediabetes. Db/db mice showed an age-dependent cortical and hippocampal atrophy, whereas in HFD mice cortex and hippocampus were preserved. We also detected increased neurogenesis and cell proliferation rates in young db/db mice when compared with control littermates. Our study shows that metabolic parameters serve as predictors of both atrophy and altered proliferation and neurogenesis in the CNS. Moreover in the cortex, atrophy, cell proliferation and neurogenesis were significantly correlated. Our data suggest that T2D may underline some of the pathological features observed in the dementia process. They also support that blood glucose control in elderly patients could help to slow down dementia evolution and maybe, improve its prognosis.
SN 1932-6203
YR 2014
FD 2014-02-20
LK http://hdl.handle.net/10498/34805
UL http://hdl.handle.net/10498/34805
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026