RT journal article
T1 Health-related quality of life in patients with primary Sjögren's syndrome: relationship with serum levels of proinflammatory cytokines.
A1 Baturone, Rocio
A1 Soto, María José
A1 Márquez Coello, María de las Mercedes
A1 Macias, Inmaculada
A1 de Oca, Montes Montserrat
A1 Medina, Fermin
A1 Chozas Candanedo, Nicolás
A1 García-Perez, S
A1 Girón González, José Antonio
AB Objective: A cross-sectional study of 30 patients with primary Sjo ̈gren’s syndrome (pSS) was performed to analyse the health-related quality of life and its relationship with serum levels of macrophage- and lymphocyte- derived cytokines.Patients and methods: Health-related quality of life was evaluated using the 36-item Short Form Health Survey (SF-36). Serum levels of interleukin (IL)-1b, IL-6, IL-10, tumour necrosis factor (TNF)-a, and gamma- interferon (g-INF) were analysed by a sandwich immunoassay-based protein array system.Results: Each of the eight scales of the SF-36 evaluating quality of life, as well as the physical composite score (PCS) and the mental composite score (MCS), showed a decrease in pSS patients. Similarly, patients with pSS showed significantly increased concentrations of each of the five cytokines analysed, when compared with the healthy control group (n 20). In pSS patients, a significant negative correlation was detected between serum levels of IL-6 and the PCS of the SF-36. Those patients with concentrations of IL-6 higher than those of the healthy controls showed a significantly lower score in the dimensions of bodily pain and physical functioning, and in the PCS.Conclusions: Patients with pSS showed increased levels of several macrophage- and lymphocyte-derived cytokines, indicating the existence of an immune activation state. Serum levels of one of these cytokines, IL-6, were correlated with poor quality of life in these individuals.
PB TAYLOR & FRANCIS LTD
SN 0300-9742
YR 2009
FD 2009-10-08
LK http://hdl.handle.net/10498/34947
UL http://hdl.handle.net/10498/34947
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 15-nov-2026