RT journal article
T1 Implications of immunomodulatory interleukins for the hyperimmunoglobulinemia of Sjögren's syndrome
A1 Girón González, José Antonio
A1 Baturone, Rocio
A1 Soto, Maria José
A1 Márquez Coello, María de las Mercedes
A1 Macias, Inmaculada
A1 Montes de Oca, Montserrat
A1 Medina, Fermín
A1 Chozas Candanedo, Nicolás
A1 García-Perez, S
A2 BiomedicinaBiotecnología y Salud Pública
AB A prospective study of 37 patients with pSS and 20 healthy controls was performed to analyze the differences in circulating levels of macrophage-derived and Th1/Th2 cytokines which could explain the hyperimmunoglobulinemia, characteristic of primary Sjögren’s syndrome (pSS). Serum levels of interleukin (IL)-6, IL-10, IL-12, gamma-interferon (γ-INF) and IL-4 were analyzed by a sandwich immunoassay-based protein array system. When compared with the control group, higher levels of IL-6, IL-12 and IL-10 and a lower Th1/Th2 ratio, as demonstrated by the γ-INF/IL-4 ratio, were detected in patients. The levels of IL-4 were notably higher in pSS patients with monoclonal gammopathy. Serum IL-4 and IL-10 levels and immunoglobulin G concentrations were significantly correlated. In conclusion, patients with pSS show a state of macrophage and T-lymphocyte activation with increased concentrations of cytokines implicated in the differentiation of B cells and secretion of immunoglobulins.
PB Elsevier
SN 0008-8749
YR 2009
FD 2009-06-06
LK http://hdl.handle.net/10498/34948
UL http://hdl.handle.net/10498/34948
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 15-nov-2026