RT journal article
T1 Bacterial translocation in HIV-infected patients with HCV cirrhosis: implication in hemodynamic alterations and mortality.
A1 de Oca Arjona, Montserrat Montes
A1 Márquez Coello, María de las Mercedes
A1 Soto, María José
A1 Rodríguez-Ramos, Claudio
A1 Terrón, Alberto
A1 Vergara, Antonio
A1 Arizcorreta, Ana
A1 Fernández Gutiérrez del Alamo, Clotilde
A1 Girón González, José Antonio
A2 BiomedicinaBiotecnología y Salud Pública
AB Objective: Analysis of the influence of portal hypertension on intestinal permeability in HIV-infected patients with hepatitis C virus (HCV)–related cirrhosis and of the prognostic significance of consequent macrophage activation.Methods: Twenty HIV-monoinfected patients, 70 patients with HIV-HCV coinfection, 20 of them with compensated and 50 with decompensated cirrhosis, and 20 healthy controls were evaluated for intestinal permeability [measured by lipopolysaccharide-binding protein (LBP) serum levels], macrophage activation [soluble CD14, soluble tumour necrosis factor receptor 55 Kd, and interleukin 6 (IL-6)], and activation of the rennin-angiotensin–aldosterone axis. Patients with decompensated cirrhosis were monitored for a median period of 429 days to analyze the prognostic factors implicated in survival.Results: Patients with decompensated cirrhosis show increased LBP levels compared with HIV-monoinfected patients. Patients with increased LBP concentration showed elevated soluble CD14, soluble tumour necrosis factor receptor 55 Kd, and IL-6 levels. Twenty-two patients died, from liver-related causes, during the follow-up, and 2 more underwent liver transplantation. Child-Pugh index, CD4 T-cell count, plasma aldosterone and serum IL-6 concentrations indepen- dently predicted liver-related mortality.Conclusions: Increased intestinal permeability, as measured by serum LBP levels, observed in patients with HIV infection is significantly higher in patients with decompensated liver cirrhosis. Proinflammatory cytokines (IL-6) are prognostic markers of HIV-HCV–coinfected patients with decompensated cirrhosis.
PB Wolters
SN 1525-4135
YR 2011
FD 2011-04-15
LK http://hdl.handle.net/10498/34952
UL http://hdl.handle.net/10498/34952
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 15-nov-2026