RT journal article
T1 Glucose and Fatty Acid Metabolism in Placental Explants From Pregnancies Complicated With Gestational Diabetes Mellitus
A1 Visiedo García, Francisco Manuel
A1 Bugatto González, Fernando
A1 Quintero Prado, Rocío
A1 Cózar Castellano, Irene
A1 Bartha Rasero, Jose luis
A1 Perdomo Hernandez, German
A2 Anatomía y Embriología Humana
K1 fatty acid oxidation
K1 glucose uptake
K1 gestational diabetes mellitus
K1 placental villous explants
AB Placental metabolism is an important mechanism for the regulation of fetal growth and long-term health of the newborns. In this study, we investigated the effects of maternal metabolic environment on human placental fatty acid and glucose metabolism. We used placental explants from uncomplicated pregnancies or pregnancies complicated with gestational diabetes mellitus (GDM), undergoingvaginal delivery (VD) or cesarean section (CS). Fatty acid oxidation (FAO) and glucose uptake (2-DOG) were similar in both modes of delivery in normal and GDM pregnancies. However, placental explants from GDM exhibited 40% to 50% reduced FAO capacity compared to control placentas in women undergoing VD or CS. In contrast, 2-DOG uptake was 2- to 3-fold higher in placental explants from GDM compared to control placentas in women undergoing VD or CS, respectively. In conclusion, ex vivo placental fuel selection is influenced by maternal GDM, but placental metabolic characteristics are not altered by the mode of delivery.
PB SAGE PUBLICATIONS INC/ SPRINGER HEIDELBERG
SN 1933-7191
YR 2015
FD 2015
LK http://hdl.handle.net/10498/35068
UL http://hdl.handle.net/10498/35068
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026