RT journal article
T1 Influence of a Concurrent Exercise Training Program During Pregnancy on Colostrum and Mature Human Milk Inflammatory Markers: Findings From the GESTAFIT Project
A1 Aparicio, Virginia Ariadna
A1 Ocón, Olga
A1 Díaz-Castro, Javier
A1 Acosta-Manzano, Pedro
A1 Coll-Risco, Irene
A1 Borges Cosic, Milkana María
A1 Romero-Gallardo, Lidia
A1 Moreno-Fernández, Jorge
A1 Ochoa-Herrera, Julio J
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 breastfeeding
K1 colostrum
K1 human milk
K1 milk composition
K1 program evaluation
AB *Background: Although exercise reduces systemic inflammation, information regarding its influence on human milk is scarce or inexistent.*Research Aim: The aim of this study was to investigate the influence of an exercise intervention during pregnancy on colostrum and mature human milk inflammatory markers. *Methods: The authors conducted a pseudorandomized controlled trial. The exercise group followed a concurrent aerobic and strength training, three 60-minutes sessions per week, from the 17th gestational week until delivery. For the specific aims of this study, only women able to produce enough milk were included for data analyses, resulting in 24 exercise and 23 control women. Colostrum and mature human milk proinflammatory and anti-inflammatory cytokines (fractalkine, interleukin [IL]–1β, IL-6, IL-8, IL-10, interferon [IFN]–γ, and tumor necrosis factor [TNF]–α) were measured using Luminex xMAP technology. *Results: The mothers who followed the exercise program had 36% lower IL-8 and 27% lower TNF-α concentrations in their colostrum than those in the control group (p < .05 and p < .01, respectively). The colostrum from mothers who followed the exercise program also presented borderline significant 22% lower IL-6 (p < .100). The mature milk from mothers who followed the exercise program had 30% greater fractalkine (p = .05) and borderline significant 20% higher IL-10 (p = .100). The exercise intervention did not affect IFN-γ concentrations. *Conclusions: This concurrent exercise program promoted a less proinflammatory profile in human milk, especially in colostrum. Moreover, it might increase mature human milk fractalkine, which could induce a greater neurodevelopment and neuroprotection in the newborn. This trial was registered at ClinicalTrials.gov (NCT02582567) on October 20, 2015.
PB SAGE
SN 1552-5732
YR 2018
FD 2018
LK http://hdl.handle.net/10498/35105
UL http://hdl.handle.net/10498/35105
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026