RT journal article
T1 High performance multi-core iron oxide nanoparticles for magnetic hyperthermia: microwave synthesis, and the role of core-to-core interactions
A1 Blanco-Andújar, Cristina
A1 Ortega Ponce, Daniel
A1 Southern, Paul
A1 Pankhurst, Quentin Andrew
A1 Thanh, Nguyen Thi Kim
A2 Física de la Materia Condensada
K1 microwave synthesis
K1 magnetic hyperthermia
K1 magnetic nanoparticles
K1 interparticle interactions
AB The adoption of magnetic hyperthermia as either a stand-alone or adjunct therapy for cancer is still far from being optimised due to the variable performance found in many iron oxide nanoparticle systems, including commercially available formulations. Herein, we present a reproducible and potentially scalable microwave-based method to make stable citric acid coated multi-core iron oxide nanoparticles, with exceptional magnetic heating parameters, viz. intrinsic loss parameters (ILPs) of up to 4.1 nH m2 kg−1, 35% better than the best commercial equivalents. We also probe the core-to-core magnetic interactions in the particles via remanence-derived Henkel and ΔM plots. These reveal a monotonic dependence of the ILP on the magnetic interaction field Hint, and show that the interactions are demagnetising in nature, and act to hinder the magnetic heating mechanism.
YR 2014
FD 2014-12-03
LK http://hdl.handle.net/10498/35261
UL http://hdl.handle.net/10498/35261
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026