RT journal article
T1 In vivo early tumor detection by infrared luminescence transient nanothermometry
A1 Santos, Harrisson D. A.
A1 Ximendes, Erving C.
A1 Iglesias de la Cruz, María del Carmen
A1 Chaves-Coira, Irene
A1 Del Rosal, Blanca
A1 Jacinto, Carlos
A1 Monge, Luis
A1 Rubia-Rodríguez, Irene
A1 Ortega Ponce, Daniel
A1 Mateos, Sergio
A1 García-Solé, Jose
A1 Jaque, Daniel
A1 Fernández, Nuria
A2 Física de la Materia Condensada
K1 Ag2S nanoparticles
K1 early tumor detection
K1 luminescence thermometry
K1 NIR in vivo imaging
AB The development of technologies capable of early tumor detection is unquestionably demanded by physicians, as early diagnosis is key to achieve more efficient and less invasive treatments with improved outcomes. At the preclinical level, nanotechnology has already provided innovative solutions for tumor imaging and therapy, but it has failed to provide real early tumor diagnosis. In this work, an infrared nanothermometry-based approach toward early melanoma detection, based on the changes produced in the thermal relaxation dynamics of tissues as the tumor develops, is introduced. In vivo experiments demonstrate that detection of incipient tumors from their very onset is possible through monitoring changes in their thermal relaxation dynamics using Ag2S infrared luminescent nanothermometers. For a total tumor development time of 14 days, luminescence nanothermometry allows tumor detection 6 days before its presence is evident by visual inspection. Simultaneous study of the tumoral vasculature reveals that the premature variation in the thermal relaxation dynamics is a consequence of the interplay between tumor angiogenesis and necrosis during the different tumor development stages.
SN 1616-3028
YR 2018
FD 2018-10-24
LK http://hdl.handle.net/10498/35270
UL http://hdl.handle.net/10498/35270
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026