RT journal article
T1 Challenges and recommendations for magnetic hyperthermia characterization measurements
A1 Wells, James
A1 Ortega Ponce, Daniel
A1 Steinhoff, Uwe
A1 Dutz, Silvio
A1 Garaio, Eneko
A1 Sandre, Olivier
A1 Natividad, Eva
A1 Cruz, Maria Margarida
A1 Brero, Francesca
A1 Southern, Paul
A1 Pankhurst, Quentin Andrew
A1 Spassov, Simo
A2 Física de la Materia Condensada
K1 thermal dosimetry
K1 thermal ablation
K1 quality assurance
K1 physics
K1 thermal dose
AB PurposeThe localized heating of magnetic nanoparticles (MNPs) via the application of time-varying magnetic fields – a process known as magnetic field hyperthermia (MFH) – can greatly enhance existing options for cancer treatment; but for broad clinical uptake its optimization, reproducibility and safety must be comprehensively proven. As part of this effort, the quantification of MNP heating – characterized by the specific loss power (SLP), measured in W/g, or by the intrinsic loss power (ILP), in Hm2/kg – is frequently reported. However, in SLP/ILP measurements to date, the apparatus, the analysis techniques and the field conditions used by different researchers have varied greatly, leading to questions as to the reproducibility of the measurements.Materials and MethodsAn interlaboratory study (across N = 21 European sites) of calorimetry measurements that constitutes a snapshot of the current state-of-the-art within the MFH community has been undertaken. Identical samples of two stable nanoparticle systems were distributed to all participating laboratories. Raw measurement data as well as the results of in-house analysis techniques were collected along with details of the measurement apparatus used. Raw measurement data was further reanalyzed by universal application of the corrected-slope method to examine relative influences of apparatus and results processing.ResultsThe data show that although there is very good intralaboratory repeatability, the overall interlaboratory measurement accuracy is poor, with the consolidated ILP data having standard deviations on the mean of ca. ± 30% to ± 40%. There is a strong systematic component to the uncertainties, and a clear rank correlation between the measuring laboratory and the ILP. Both of these are indications of a current lack of normalization in this field. A number of possible sources of systematic uncertainties are identified, and means determined to alleviate or minimize them. However, no single dominant factor was identified, and significant work remains to ascertain and remove the remaining uncertainty sources.ConclusionWe conclude that the study reveals a current lack of harmonization in MFH characterization of MNPs, and highlights the growing need for standardized, quantitative characterization techniques for this emerging medical technology.
SN 1464-5157
YR 2021
FD 2021-03-17
LK http://hdl.handle.net/10498/35271
UL http://hdl.handle.net/10498/35271
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026