RT journal article
T1 Integrated modeling of labile and glycated hemoglobin with glucose for enhanced diabetes detection and short-term monitoring
A1 Romero Rosales, José Antonio
A1 Aragonés, David G.
A1 Escribano Serrano, José
A1 González Borrachero, Marisa
A1 Michán Doña, Alfredo
A1 Macías López, Francisco J.
A1 Santos Mata, María Ángeles
A1 Naranjo Jiménez, Inmaculada
A1 Casamitjana Zamora, María Jesús
A1 Serrano, Hélia
A1 Belmonte Beitia, Juan
A1 Rosa Durán, María
A1 Calvo, Gabriel F.
A2 Matemáticas
AB Metabolic biomarkers, particularly glycated hemoglobin and fasting plasma glucose, are pivotal in the diagnosis and control of diabetes mellitus. Despite their importance, they exhibit limitations in assessing short-term glucose variations. In this study, we propose labile hemoglobin as an additional biomarker, providing insightful perspectives into these fluctuations. By utilizing datasets from 40,652 retrospective general participants and conducting glucose tolerance tests on 60 prospective pediatric subjects, we explored the relationship between plasma glucose and labile hemoglobin. A mathematical model was developed to encapsulate short-term glucose kinetics in the pediatric group. Applying dimensionality reduction techniques, we successfully identified participant subclusters, facilitating the differentiation between diabetic and non-diabetic individuals. Intriguingly, by integrating labile hemoglobin measurements with plasma glucose values, we were able to predict the likelihood of diabetes in pediatric subjects, underscoring the potential of labile hemoglobin as a significant glycemic biomarker for diabetes research.
PB Elsevier Inc.
SN 2589-0042
YR 2024
FD 2024
LK http://hdl.handle.net/10498/35572
UL http://hdl.handle.net/10498/35572
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026