RT journal article
T1 Device-measured sedentary time and intensity-specific physical activity in relation to all-cause and cardiovascular disease mortality: the UK Biobank cohort study
A1 Rezende, L. F. M.
A1 Ahmadi, M. N.
A1 Ferrari, Gerson
A1 Pozo Cruz, Borja del
A1 Lee, I. M.
A1 Ekelund, Ulf
A1 Stamatakis, Emmanuel
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 Accelerometer
K1 All-cause mortality
K1 Cardiovascular disease mortality
K1 Physical activity
K1 Sedentary behaviour
AB Background and aims: Understanding the amounts of intensity-specific movement needed to attenuate the association between sedentary time and mortality may help to inform personalized prescription and behavioral counselling. Herein, we examined the joint associations of sedentary time and intensity-specific physical activity with all-cause and cardiovascular disease (CVD) mortality. Methods: Prospective cohort study including 73,729 adults from the UK Biobank who wore an Axivity AX3 accelerometer on their dominant wrist for at least 3 days, being one a weekend day, between June 2013 and December 2015. We considered the median tertile values of sedentary time and physical activity in each intensity band to determine the amount of physical activity needed to attenuate the association between sedentary time and mortality. Results: During a median of 6.9 years of follow-up (628,807 person-years), we documented 1521 deaths, including 388 from CVD. Physical activity of any intensity attenuated the detrimental association of sedentary time with mortality. Overall, at least a median of 6 min/day of vigorous physical activity, 30 min/day of MVPA, 64 min/day of moderate physical activity, or 163 min/day of light physical activity (mutually-adjusted for other intensities) attenuated the association between sedentary time and mortality. High sedentary time was associated with higher risk of CVD mortality only among participants with low MVPA (HR 1.96; 95% CI 1.23 to 3.14). Conclusions: Different amounts of each physical activity intensity may attenuate the association between high sedentary time and mortality.
PB BioMed Central Ltd
SN 1479-5868
YR 2024
FD 2024
LK http://hdl.handle.net/10498/35574
UL http://hdl.handle.net/10498/35574
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 09-may-2026