RT journal article
T1 The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic
A1 Casimiro Soriguer, Carlos S.
A1 Perez Florido, Javier
A1 Robles, Enrique
A1 Lara, María
A1 Aguado, Andrea
A1 Rodríguez Iglesias, Manuel Antonio
A1 Lepe, Jose A.
A1 García, Federico
A1 Pérez Alegre, Mónica
A1 Andújar, Eloísa
A1 Jiménez, Victoria E.
A1 Camino, Lola P.
A1 Loruso, Nicola
A1 Ameyugo, Ulises
A1 Vazquez, Isabel María
A1 Lozano, Carlota M.
A1 Chaves, J. Alberto
A1 Dopazo, Joaquín
A2 BiomedicinaBiotecnología y Salud Pública
AB The One Health approach, recognizing the interconnectedness of human, animal, and environmental health, has gained significance amid emerging zoonotic diseases and antibiotic resistance concerns. This paper aims to demonstrate the utility of a collaborative tool, the SIEGA, for monitoring infectious diseases across domains, fostering a comprehensive understanding of disease dynamics and risk factors, highlighting the pivotal role of One Health surveillance systems. Raw whole-genome sequencing is processed through different species-specific open software that additionally reports the presence of genes associated to anti-microbial resistances and virulence. The SIEGA application is a Laboratory Information Management System, that allows customizing reports, detect transmission chains, and promptly alert on alarming genetic similarities. The SIEGA initiative has successfully accumulated a comprehensive collection of more than 1900 bacterial genomes, including Salmonella enterica, Listeria monocytogenes, Campylobacter jejuni, Escherichia coli, Yersinia enterocolitica and Legionella pneumophila, showcasing its potential in monitoring pathogen transmission, resistance patterns, and virulence factors. SIEGA enables customizable reports and prompt detection of transmission chains, highlighting its contribution to enhancing vigilance and response capabilities. Here we show the potential of genomics in One Health surveillance when supported by an appropriate bioinformatic tool. By facilitating precise disease control strategies and antimicrobial resistance management, SIEGA enhances global health security and reduces the burden of infectious diseases. The integration of health data from humans, animals, and the environment, coupled with advanced genomics, underscores the importance of a holistic One Health approach in mitigating health threats.
PB Springer Nature
SN 2045-2322
YR 2024
FD 2024-08-19
LK http://hdl.handle.net/10498/35607
UL http://hdl.handle.net/10498/35607
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026