RT journal article
T1 Extraction of Bioactive Compounds from Wine Lees: A Systematic and Bibliometric Review
A1 De Oliveira Melo, Filipe
A1 Cosme Ferreira, Vanessa
A1 Fernández Barbero, Gerardo
A1 Carrera Fernández, Ceferino Adrián
A1 De Souza Ferreira, Ederlan
A1 Umsza Guez, Marcelo Andrés
A2 Química Analítica
K1 phenolic compounds
K1 ultrasound
K1 waste
K1 wine
K1 anthocyanins
AB The extraction of bioactive compounds from wine lees involves a variety of methods, theselection of which is crucial to ensure optimal yields. This systematic review, following PRISMAguidelines and utilizing the Web of Science database, aimed to examine the current state of thisfield, providing insights for future investigations. The search employed strategies with truncationtechniques and Boolean operators, followed by a three-step screening using well-defined eligibilitycriteria. A bibliometric analysis was conducted to identify authors, affiliations, countries/regions,and research trends. Thirty references were selected for analysis, with Spain standing out as themain source of research on the topic. The majority of studies (66%) focused on the extraction ofbioactive compounds from alcoholic fermentation lees, while 33% were directed towards malolacticfermentation lees. Binary mixtures (ethanol–water) were the predominant solvents, with ultrasoundbeing the most used extraction method (31.3%), providing the highest average yields (288.6%) forthe various evaluated compounds, especially flavonoids. The potential of wine lees as a source ofbioactive compounds is highlighted, along with the need for further research exploring alternativeextraction technologies and the combination of methods. Additionally, the importance of “in vitro”and “in vivo” tests to assess the bioactive potential of lees, as well as the use of computational toolsto optimize extraction and identify the molecules responsible for bioactive activity, is emphasized.
PB MDPI
SN 2304-8158
YR 2024
FD 2024
LK http://hdl.handle.net/10498/35698
UL http://hdl.handle.net/10498/35698
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026