RT journal article
T1 Advancements in Pharmacological Interventions and Novel Therapeutic Approaches for Amyotrophic Lateral Sclerosis
A1 Montiel-Troya, María
A1 Mohamed-Mohamed, Himan
A1 Pardo-Moreno, Teresa
A1 González-Díaz, Ana
A1 Rúger Navarrete, Azahara
A1 de la Mata Fernández, Mario
A1 Tovar Gálvez, María Isabel
A1 Ramos-Rodríguez, Juan José
A1 García Morales, Victoria
A2 BiomedicinaBiotecnología y Salud Pública
K1 ALS
K1 amyotrophic lateral sclerosis
K1 motor neuron dysfunction
K1 multidisciplinary treatment
K1 neurodegenerative disorder
K1 pharmacological interventions
AB (1) Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease in which the patient suffers from an affection of both upper and lower motor neurons at the spinal and brainstem level, causing a progressive paralysis that leads to the patient’s demise. Gender is also considered a predisposing risk factor for developing the disease. A brief review of the pathophysiological mechanisms of the disease is also described in this work. Despite the fact that a cure for ALS is currently unknown, there exists a variety of pharmacological and non-pharmacological therapies that can help reduce the progression of the disease over a certain period of time and alleviate symptoms. (2) We aim to analyze these pharmacological and non-pharmacological therapies through a systematic review. A comprehensive, multidisciplinary approach to treatment is necessary. (3) Drugs such as riluzole, edaravone, and sodium phenylbutyrate, among others, have been investigated. Additionally, it is important to stay updated on research on new drugs, such as masitinib, from which very good results have been obtained. (4) Therapies aimed at psychological support, speech and language, and physical therapy for the patient are also available, which increase the quality of life of the patients.
PB Multidisciplinary Digital Publishing Institute (MDPI)
SN 2227-9059
YR 2024
FD 2024
LK http://hdl.handle.net/10498/35837
UL http://hdl.handle.net/10498/35837
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026