RT journal article
T1 Dereplication of New Saponins from Agave bracteosa
A1 Guzzo, Francesca
A1 García Durán, Alexandra
A1 Rostoll, Laura L.
A1 Macías Domínguez, Francisco Antonio
A1 Simonet Morales, Ana María
A2 Química Orgánica
K1 (25S)-cantalasaponin-1
K1 Agave bracteosa
K1 Agave bracteosa
K1 dereplication
K1 furostane
K1 HMAI
K1 saponins
AB The genus Agave comprises over 400 species that are known for their diverse applications, which include being sources of fiber, food, and beverages. There has recently been increased interest in exploring the metabolic content of this genus, and in this respect, saponins are the main compounds of interest. Saponins for Agave bracteosa have not been described to date, and the current work addresses the dereplication of a saponin-rich fraction to identify the structures of six compounds. The dereplication methods involve the use of UPLC-MSE analysis, NMR spectroscopy and published data for Agave saponins. A green extraction and isolation provided ten pure saponins. Remarkably, nine of these saponins have not been reported previously, namely (25S)-cantalasaponin-1 and bractofuranosides A–H. These compounds were tested for cytotoxic activity. Bractofuranosides B (5) and G (10) displayed 57% and 53% cell viability on HeLa cells at 100 µM, respectively.
PB Multidisciplinary Digital Publishing Institute (MDPI)
SN 2223-7747
YR 2024
FD 2024
LK http://hdl.handle.net/10498/35840
UL http://hdl.handle.net/10498/35840
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026