RT journal article
T1 The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018)
A1 Gracia Ahufinger, Irene
A1 López González, Laura
A1 Vasallo, Francisco José
A1 Galar, Alicia
A1 Siller, María
A1 Pitart, C.
A1 Bloise, I.
A1 Torrecillas, Miriam
A1 Gijón-Cordero, Desireé
A1 Viñado, Belén
A1 Castillo-García, Javier
A1 Campo, Rainer
A1 Mulet, Xavier
A1 Madueño-Alonso, Ana
A1 Chamizo-López, Francisco Javier
A1 Arrastia-Erviti, Maitane
A1 Galán Sánchez, Fátima
A1 Fernández-Quejo, Melisa
A1 Rodríguez-Díaz, Juan Carlos
A1 Gutiérrez-Zufiaurre, María Nieves
A1 Rodríguez-Maresca, Manuel Ángel
A1 Ortega-Lafont, María del Pilar
A1 Yagüe-Guirao, Genoveva
A1 Chaves-Blanco, Lucía
A1 Chaves-Blanco, Javier
A1 Colomina-Rodríguez, Javier
A1 Vidal-Acuña, María Reyes
A1 Portillo, María Eugenia
A1 Franco-Álvarez de Luna, Francisco
A1 Centelles-Serrano, M.J.
A1 Azcona-Gutiérrez, José Manuel
A1 Delgado-Iribarren García Campero, Alberto
A1 Rey-Cao, Sonia
A1 Muñoz, Patricia
A1 Calvo-Montes, Jorge
A1 Zboromyrska, Yuliya
A1 Grandioso, David
A1 Cámara, Jordi
A1 Cantón, Rafael
A1 Larrosa-Escartín, Nieves
A1 Díaz-Regañón, Jazmín
A1 Martínez-Martínez, Luis
A2 BiomedicinaBiotecnología y Salud Pública
K1 Klebsiella pneumoniae
K1 Escherichia coli
K1 Enterobacter cloacae complex
K1 Klebsiella (Enterobacter) aerogenes
K1 Pseudomonas aeruginosa
K1 carbapenemases
K1 geographical distribution
AB Introduction: Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa, including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution of the different carbapenemases among carbapenemase-producing Enterobacterales (CPE, specifically Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, and Klebsiella aerogenes) and carbapenemase-producing P. aeruginosa (CPPA) in Spain from January 2014 to December 2018. Methods: A national, retrospective, cross-sectional multicenter study was performed. The study included the first isolate per patient and year obtained from clinical samples and obtained for diagnosis of infection in hospitalized patients. A structured questionnaire was completed by the participating centers using the REDCap platform, and results were analyzed using IBM SPSS Statistics 29.0.0. Results: A total of 2,704 carbapenemase-producing microorganisms were included, for which the type of carbapenemase was determined in 2692 cases: 2280 CPE (84.7%) and 412 CPPA (15.3%), most often using molecular methods and immunochromatographic assays. Globally, the most frequent types of carbapenemase in Enterobacterales and P. aeruginosa were OXA-48-like, alone or in combination with other enzymes (1,523 cases, 66.8%) and VIM (365 cases, 88.6%), respectively. Among Enterobacterales, carbapenemase-producing K. pneumoniae was reported in 1821 cases (79.9%), followed by E. cloacae complex in 334 cases (14.6%). In Enterobacterales, KPC is mainly present in the South and South-East regions of Spain and OXA-48-like in the rest of the country. Regarding P. aeruginosa, VIM is widely distributed all over the country. Globally, an increasing percentage of OXA-48-like enzymes was observed from 2014 to 2017. KPC enzymes were more frequent in 2017–2018 compared to 2014–2016. Discussion: Data from this study help to understand the situation and evolution of the main species of CPE and CPPA in Spain, with practical implications for control and optimal treatment of infections caused by these multi-drug resistant organisms.
PB Frontiers Media SA
SN 1664-302X
YR 2023
FD 2023
LK http://hdl.handle.net/10498/35863
UL http://hdl.handle.net/10498/35863
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026