RT journal article
T1 Interneuron diversity in the human dorsal striatum
A1 Garma, Leonardo D.
A1 Harder, Lisbeth
A1 Barba Reyes, Juan Manuel
A1 Marco Salas, Sergio
A1 Díez Salguero, Mónica
A1 Nilsson, Mats
A1 Serrano Pozo, Alberto
A1 Hyman, Bradley T.
A1 Muñoz Manchado, Ana Belén
A2 Neurociencias
AB Decipheringthestriatal interneurondiversity iskey tounderstandingthebasal ganglia circuit and to untangling the complex neurological and psychiatric diseases affecting this brain structure. We performed snRNA-seq and spatial transcriptomics of postmortemhumancaudatenucleusandputamensamples to elucidate the diversity and abundance of interneuron populations and their inherent transcriptional structure in the human dorsal striatum. We propose a comprehensive taxonomy of striatal interneurons with eight main classes and fourteen subclasses, providing their full transcriptomic identity and spatial expression profile as well as additional quantitative FISH validation for specific populations. We have also delineated the correspondence of our taxonomy with previous standardized classifications and shown the main transcriptomic and class abundance differences between caudate nucleus and putamen. Notably, based on key functional genes such as ion channels and synaptic receptors, we found matching known mouse interneuron populations for the most abundant populations, the recently described PTHLH and TAC3 interneurons. Finally, we were able to integrate other published datasets with ours, supporting the generalizability of this harmonized taxonomy.
PB Nature Research
SN 2041-1723
YR 2024
FD 2024
LK http://hdl.handle.net/10498/35864
UL http://hdl.handle.net/10498/35864
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026