RT journal article
T1 Multifunctional Heterogeneous Cobalt Catalyst for the One-Pot Synthesis of Benzimidazoles by Reductive Coupling of Dinitroarenes with Aldehydes in Water
A1 del Río-Rodríguez, José Luis
A1 Gutiérrez Tarriño, Silvia
A1 Chinchilla Reyes, Lidia Esther
A1 Holgado, Juan Pedro
A1 Villar García, Ignacio J.
A1 Pérez Dieste, Virginia
A1 Calvino Gámez, José Juan
A1 Oña Burgos, Pascual
A2 Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica
K1 Benzimidazoles
K1 Heterogeneous catalysis
K1 Hydrogenative coupling
K1 One-pot reactions
K1 Sustainablechemistry
AB The endeavor of sustainable chemistry has led to significant advancements in green methodologies aimed at minimizing environmental impact while maximizing efficiency. Herein, a straightforward synthesis of benzimidazoles by reductive coupling of o-dinitroarenes with aldehydes is reported for the first time in aqueous media while using a non-noble metal catalyst. This work demonstrates that the combination of nitrogen and phosphorous ligands in the synthesis of supported heteroatom-incorporated Co nanoparticles is crucial for obtaining the desired benzimidazoles. The process achieves >99 % conversion, >99 % chemoselectivity and stability for the reduction of dinitroarenes using water as the solvent and hydrogen as the reductant under mild reaction conditions. The robustness of the catalyst has been investigated using several advanced techniques such as HRTEM, HAADF-STEM, XEDS, EELS, and NAP-XPS. In fact, we have shown that the introduction of N and P dopants prevents metal leaching and the sintering of the cobalt nanoparticles. Finally, to explore the general catalytic performance, a wide range of substituted dinitroarenes and benzaldehydes were evaluated, yielding benzimidazoles with competitive and scalable results, including MBIB (94 % yield), which is a compound of pharmaceutical interest.
PB Wiley
SN 1864-564X
YR 2024
FD 2024-12-09
LK http://hdl.handle.net/10498/35894
UL http://hdl.handle.net/10498/35894
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 13-nov-2026