RT journal article T1 Effectiveness of Nintendo Wii Fit© for Physical Therapy in Patients with Multiple Sclerosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials A1 Alba Rueda, Alvaro A1 De Miguel Rubio, Amaranta A1 Lucena Antón, David Manuel A2 Enfermería y Fisioterapia K1 multiple sclerosis K1 exergaming K1 videogames K1 exercise K1 physical therapy K1 neurological rehabilitation K1 systematic review K1 meta-analysis AB Multiple sclerosis (MS) is a chronic, inflammatory, and autoimmune disease that mainlyaffects the central nervous system and currently has no cure. Exergaming is considered a nonimmersiveapproach to improving functional and motor skills in the treatment of MS. The aim ofthis systematic review was to evaluate the effectiveness of the Nintendo Wii Fit© (NWF) on physicaloutcomes compared with control regimes in patients with MS. The search was performed in sevendatabases including articles published up to June 2024. The PICOS model was used to establish thestudy eligibility criteria. The Cochrane Collaboration tool and the PEDro scale were used to assessthe risk of bias and evaluate the methodological quality of the studies, respectively. A meta-analysisusing the standardized mean difference (SMD) and confidence interval (95% CI) was developedusing the Review Manager 5.4 software. Seven articles were included in the systematic review. Thestatistical analysis showed favorable overall results for the NWF on functional mobility (SMD = 0.25;95% CI = 0.09, 0.41) and fatigue (SMD = 0.41; 95% CI = 0.00, 0.82). In conclusion, this systematicreview suggests that the NWF has shown favorable effects compared to control regimes on functionalmobility and fatigue outcomes in patients with MS. PB MDPI SN 2075-4426 YR 2024 FD 2024-08-24 LK http://hdl.handle.net/10498/36152 UL http://hdl.handle.net/10498/36152 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 09-nov-2026