RT journal article T1 Machine learning techniques for predicting neurodevelopmental impairments in premature infants: a systematic review A1 Ortega León, Arantxa Mireya A1 Urda, Daniel A1 Turias Domínguez, Ignacio José A1 Lubián López, Simón Pedro A1 Benavente Fernández, Isabel A2 Ingeniería Informática A2 Materno-Infantil y Radiología K1 machine learning K1 preterm infants K1 neurodevelopmental impairment K1 NDIs prediction K1 NDIs prognosis AB Background and objective: Very preterm infants are highly susceptible to Neurodevelopmental Impairments (NDIs), including cognitive, motor, and language deficits. This paper presents a systematic review of the application of Machine Learning (ML) techniques to predict NDIs in premature infants. Methods: This review presents a comparative analysis of existing studies from January 2018 to December 2023, highlighting their strengths, limitations, and future research directions. Results: We identified 26 studies that fulfilled the inclusion criteria. In addition, we explore the potential of ML algorithms and discuss commonly used data sources, including clinical and neuroimaging data. Furthermore, the inclusion of omics data as a contemporary approach employed, in other diagnostic contexts is proposed. Conclusions: We identified limitations and emphasized the significance of employing multimodal data models and explored various alternatives to address the limitations identified in the reviewed studies. The insights derived from this review guide researchers and clinicians toward improving early identification and intervention strategies for NDIs in this vulnerable population. PB Frontiers SN 2624-8212 YR 2025 FD 2025 LK http://hdl.handle.net/10498/36355 UL http://hdl.handle.net/10498/36355 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 10-nov-2026