RT journal article
T1 Biotransformation of Thiochroman Derivatives Using Marine-Derived Fungi: Isolation, Characterization, and Antimicrobial Activity
A1 Roca Virués de Segovia, Jorge
A1 Pinedo Rivilla, Cristina
A1 Muñoz Mira, Salvador
A1 Ansino, M.
A1 González Rodríguez, Victoria Eugenia
A1 Ezzanad, Abdellah
A1 Galán Sánchez, Fátima
A1 Durán Patrón, Rosa María
A1 Aleu Casatejada, Josefina
A2 BiomedicinaBiotecnología y Salud Pública
A2 Química Orgánica
K1 antimicrobial activity
K1 biotransformation
K1 Emericellopsis maritima
K1 marine fungi
K1 Purpureocillium lilacinum
K1 thiochromanone
AB Thiochroman derivatives are highly versatile molecules widely used for the synthesis of novel heterocycles and bioactive compounds. In our study, we conducted the biotransformation of thiochroman-4-ol (1) and 6-chlorothiochroman-4-ol (1a) using the marine-derived fungal strains Emericellopsis maritima BC17 and Purpureocillium lilacinum BC17-2. Biotransformations yielded ten known thiochroman derivatives along with the compound 1-(5-chloro-2-(methylthio)phenyl)propane-1,3-diol (6a), which was described for the first time. Moreover, we successfully characterized the stereoisomers of sulfoxides 3 and 3a. Their structures and absolute configurations were established though comprehensive analyses of NMR, HR ESI-MS, and ECD spectra, as well as by using Mosher’s method. Antimicrobial activity of the isolated metabolites was evaluated against bacterial and fungal human pathogens, specifically Staphylococcus aureus ATCC 29213, Escherichia coli ATCC25922, and Candida albicans HPM-1922816.
PB Multidisciplinary Digital Publishing Institute (MDPI)
SN 1422-0067
YR 2025
FD 2025
LK http://hdl.handle.net/10498/36404
UL http://hdl.handle.net/10498/36404
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026