RT journal article T1 Necrolytic migratory erythema associated with glucagonoma treated successfully with cyclosporine A1 Jiménez Gallo, David A1 Ossorio García, Lidia A1 De la Varga Martínez, Raquel A1 Arjona Aguilera, Cintia A1 Linares Barrios, Mario Dionisio A2 Medicina AB Glucagonoma syndrome is a rare paraneoplastic syndrome characterized by elevated serum levels of glucagon, the presence of glucagonoma, and dermatological clinical findings such as necrolyticmigratory erythema (NME) (John & Schwartz, 2016; Luber, Ackerman, Culpepper, Buschmann, & Koep, 2016). The main challengeassociated with the diagnosis of glucagonoma syndrome is that atdiagnosis, metastasis has already occurred in more than 50% ofcases. However, this tumor tends to exhibit slow growth; mediansurvival is 3–7 years and patients have survived for up to 24 years(John & Schwartz, 2016; Mendoza-Guil, Hern andez-Jurado, Burkhardt, Linares, & Naranjo, 2005). Furthermore, NME significantlyaffects patients’ quality of life and is characteristically resistant totreatment (Thomaidou, Nahmias, Gilead, Zlotogorski, & Ramot,2016). In this sense, additional knowledge regarding effective drugsfor treating persistent NME is needed. PB Wiley SN 1529-8019 YR 2017 FD 2017 LK http://hdl.handle.net/10498/36540 UL http://hdl.handle.net/10498/36540 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 10-may-2026