RT journal article
T1 Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study
A1 González, Lorena
A1 Gonzalez-Riano, Carolina
A1 Fernández-García, Pablo
A1 Cereijo, Rubén
A1 Valls, Aina
A1 Soria-Gondek, Andrea
A1 Real, Nativitat
A1 Requena, Belén
A1 Bel-Comos, Joan
A1 Corrales, Patricia
A1 Jiménez Pavón, David
A1 Barbas, Coral
A1 Villarroya, Francesc
A1 Sánchez Infantes, David
A1 Murillo, Marta
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 Recombinant human growth hormone
K1 Lipidome
K1 Brown adipose tissue
K1 Small for gestational age
AB Recombinant human growth hormone (rhGH) therapy is the primary treatment for children born small for gestational age (SGA) who fail to show spontaneous catch-up growth by two or four years. While its effects on white adipose tissue are well-documented, this pilot study aimed to investigate its impact on the lipidome and the thermogenic and endocrine activities of brown adipose tissue (BAT) in SGA children following rhGH treatment. The study involved 11 SGA children divided into two groups: (a) SGA children who were not treated with rhGH (n = 4) and (b) SGA children who received rhGH treatment with Saizen® (n = 7). This second group of seven SGA children was followed for 12 months after initiating rhGH treatment. Interventions included 12-hour fasting blood extraction and infrared thermography at baseline and 3 and 12 months post-treatment. Five appropriate-for-gestational-age (AGA) children served as controls. Exclusion criteria included endocrinological, genetic, or chronic diseases. Untargeted lipidomics analysis was performed using liquid chromatography-mass spectrometry (LC-MS), and serum biomarker levels were measured using ELISA assays. Serum lipidomic analysis revealed that free fatty acids (FFAs) increased to levels close to those of the AGA group after three months of rhGH administration, including polyunsaturated fatty acids, correlating with reduced leptin levels. Elevated levels of 1a,1b-dihomo-PGJ2 and adrenic acid suggested potential aging markers. rhGH treatment also significantly reduced meteorin-like (METRNL) and monocyte chemoattractant protein-1 (MCP1) serum levels to control levels. rhGH influences the serum lipidome, promoting changes in maturation and metabolism. Further research is required to clarify the direct effects of rhGH on specific lipid species and batokines, potentially addressing metabolic disturbances linked to obesity and aging.
PB Springer Nature
SN 2045-2322
YR 2025
FD 2025
LK http://hdl.handle.net/10498/36545
UL http://hdl.handle.net/10498/36545
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026