RT journal article
T1 The transcriptional profiling of human in vivo-generated plasma cells identifies selective imbalances in monoclonal gammopathies
A1 Valor, Luis M.
A1 Rodrguez Bayona, Beatriz
A1 Ramos Amaya, Ana B.
A1 Brieva, Jose A.
A1 Campos Caro, Antonio
A2 BiomedicinaBiotecnología y Salud Pública
AB Plasma cells (PC) represent the heterogeneous final stage of the B cells (BC) differentiation process. To characterize the transition of BC into PC, transcriptomes from human naïve BC were compared tothose of three functionally-different subsets of human in vivo-generated PC: i) tonsil PC, mainly consisting of early PC; ii) PC released to the blood after a potent booster-immunization (mostly cycling plasmablasts); and, iii) bone marrow CD138 + PCthat represent highly mature PC and include the long-lived PC compartment. This transcriptional transition involves subsets of genes related to key processes for PC maturation: the already knownprotein processing, apoptosis and homeostasis, and of new discovery including histones, macromolecule assembly, zinc-finger transcription factors and neuromodulation. This humanPCsignature is partially reproduced in vitro and is conserved in mouse. Moreover, the present study identifies genes that define PC subtypes (e.g., proliferation-associated genes for circulating PC and transcriptional-related genes for tonsil and bone marrow PC)andproposes someputative transcriptional regulators of the human PC signatures (e.g., OCT/POU, XBP1/CREB,E2F, amongothers). Finally, we also identified a restricted imbalance of the present PC transcriptional program in monoclonal gammopathies that correlated with PC malignancy.
PB Public Library of Science
SN 1932-6203
YR 2017
FD 2017
LK http://hdl.handle.net/10498/36575
UL http://hdl.handle.net/10498/36575
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026