RT journal article
T1 Microneedle based electrochemical (Bio)Sensing: Towards decentralized and continuous health status monitoring
A1 García Guzmán, Juan José
A1 Pérez Ràfols, Clara
A1 Cuartero, María
A1 Crespo, Gastón A.
A2 Química Analítica
K1 Wearable sensors
K1 Microneedle (bio)sensing
K1 On-body continuos monitoring
K1 Transdermal interstitial fluid analysis
K1 Health care monitoring
AB Microneedle (MN) based electrochemical (bio)sensing has become a growing field within the disciplineof analytical chemistry as a result of its unique capacity for continuous, decentralized health statusmonitoring. There are two significant advantages to this exclusive feature: i) the ability to directlyanalyze interstitial fluid (ISF), a body fluid with a similar enough composition to plasma (and blood) to beconsidered a plentiful source of information related to biologically relevant molecules and biomarkers;and ii) the capacity to overcome some of the major limitations of blood analysis including painfulextraction, high interferant concentrations, and incompatibility with diagnosis of infants (and especiallynewborns). Recent publications have demonstrated important advancements in electrochemical MNsensor technology, among which are included new MN fabrication methods and various modificationstrategies, providing different architectures and allowing for the integration of electronics. This versatilityhighlights the undeniable need for interdisciplinary efforts towards tangible progress in the field. Ina context evidently dominated by glucose sensing, which is slowly being expanded towards otheranalytes, the following crucial questions arise: to what extent are electrochemical MN (bio)sensors areliable analytical tool for continuous ISF monitoring? Which is the best calibration protocol to be followedfor in vivo assays? Which strategies can be employed to protect the sensing element during skinpenetration? Is there an appropriate validation methodology to assess the accuracy of electrochemicalMN (bio)sensors? How significant is the distinction between successful achievements in the laboratoryand the real commercial feasibility of products? This paper aims to reflect on those previous questionswhile reviewing the progress of electrochemical MN (bio)sensors in the last decade with a focus on theanalytical aspects. Overall, we describe the current state of electrochemical MN (bio)sensors, the benefitsand challenges associated to ISF monitoring, as well as key features (and bottlenecks) regarding itsimplementation for in vivo assays
PB Elsevier
SN 1879-3142
YR 2021
FD 2021
LK http://hdl.handle.net/10498/36660
UL http://hdl.handle.net/10498/36660
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 09-nov-2026