RT journal article T1 Persistent COVID and ASD: Long-term neuropsychiatric impact and the need for personalized interventions T2 COVID Persistente y TEA: Impacto neuropsiquiátrico a largo plazo y necesidad de intervenciones personalizadas A1 Gallardo Herrerías, Celia K1 Long COVID K1 ASD K1 Autism K1 mental health K1 COVID persistente K1 TEA K1 salud mental AB The study explores the long-term neuropsychiatric impact of COVID-19 on individuals withAutism Spectrum Disorders (ASD) in order to develop effective interventions and treatments.The primary objective was to examine the impact of COVID-19 on long-termneuropsychiatric symptoms in ASD patients and determine the optimal treatment andmanagement options. A systematic review was performed using scientific databases such asPubMed, Scopus, Web of Science, and Redalyc, with major key words and strictinclusion/exclusion criteria to ensure the quality of the study. Of the 242 studies initiallyreported, 12 met all the inclusion criteria for the review. The outcomes showed that repeatCOVID aggravates pre-existing neuropsychiatric signs in ASD individuals, mainlydepression and anxiety. Meta-analysis of the combined studies showed an increase of 1.5points on a common symptom score after COVID-19. Irritability and emotion regulationwere also identified as other behavioral problems. Overall, COVID-19 impacts theneuropsychiatric health of ASD individuals adversely and demands tailored andmultidisciplinary treatment methods targeting physical as well as psychiatric symptoms. PB Editorial Uca SN 2341-3255 YR 2025 FD 2025 LK http://hdl.handle.net/10498/36743 UL http://hdl.handle.net/10498/36743 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 22-sep-2026