RT journal article
T1 Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge Neopetrosia cf. rava Collected in the Bismarck Sea
A1 Ortega-Vidal, J.
A1 Reddy, M. M.
A1 Pérez-Fuentes, N.
A1 Alvariño, R.
A1 Burth, S.
A1 Alfonso, A.
A1 Vale, C.
A1 Roca Virués de Segovia, Jorge
A1 Mungkaje, A.
A1 Botana, L. M.
A1 Thomas, O. P.
A2 Química Orgánica
AB Sponges of the genus Neopetrosia are known for theproduction of a large diversity of bioactive metabolites.Contignasterines A (1) and B (2) were isolated as majormetabolites of the sponge Neopetrosia cf. rava collected in theBismarck Sea along with the known and highly bioactive steroidcontignasterol (3) possessing a similar oxidized aglycone.Contignasterines are characterized by the presence of a 2-aminoimidazole branched on the side-chains of the oxidizedsteroid, and 1 also contains an unusual phosphate group at C-7.The anti-inflammatory activities of these compounds wereinvestigated and revealed that all three compounds inhibited theproduction of pro-inflammatory mediators
PB ACS Publications
SN 1520-6025
YR 2025
FD 2025-03-07
LK http://hdl.handle.net/10498/36918
UL http://hdl.handle.net/10498/36918
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 04-nov-2026