RT journal article
T1 Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients
A1 Barbeta, Enric
A1 Barreiros, Cláudia
A1 Forin, Edoardo
A1 Guzzardella, Amedeo
A1 Motos, Anna
A1 Fernández Barat, Laia
A1 Gabarrús, Albert
A1 Ceccato, Adrián
A1 Ferrer, Ricard
A1 Riera, Jordi
A1 Peñuelas, Oscar
A1 Lorente, José A.
A1 de Gonzalo Calvo, David
A1 González, Jessica
A1 Amaya Villar, Rosario
A1 Añón, José Manuel
A1 Balan, Ana
A1 Barberà, Carme
A1 Barberán, José
A1 Blandino, Aaron
A1 Boado, María Victoria
A1 Bustamante Munguira, Elena
A1 Caballero, Jesús
A1 Cantón-Bulnes, Luisa
A1 Carbajales, Cristina
A1 Carbonell, Nieves
A1 Catalán‑González, Mercedes
A1 Franco, Nieves
A1 Galban, Cristóbal
A1 Gumucio-Sanguino, Víctor D.
A1 de la Torre, María del Carmen
A1 Díaz, Emilio
A1 Estella García, Ángel
A1 Gallego, Elena
A1 Gómez, José Manuel
A1 Huerta, Arturo
A1 Jorge García, Ruth Noemí
A1 Loza Vázquez, Ana
A1 Marin Corral, Judith
A1 Martín Delgado, María Cruz
A1 Martínez, Amalia
A1 Martínez, Ignacio
A1 López, Juan
A1 Albaiceta, Guillermo M.
A1 Nieto, María Teresa
A1 Andrea Novo, Mariana
A1 Peñasco, Yhivian
A1 Pérez García, Felipe
A1 Ricart, Pilar
A1 Rodríguez, Alejandro
A1 Sagredo, Víctor
A1 Sánchez Miralles, Ángel
A1 Sancho, Susana
A1 Roche-Campo, Ferran
A1 Socias, Lorenzo
A1 Solé Violán, Jordi
A1 Tamayo, Luis
A1 Trenado, José
A1 Úbeda, Alejandro
A1 Valdivia, Luis Jorge
A1 Vidal, Pablo
A1 Barbé, Ferrán
A1 Vallverdú, Jordi
A1 Torres, Antoni
A1 CIBERESUCICOVID Project investigators (COV20/00110, ISCIII)
A2 Medicina
K1 Mechanical power
K1 COVID-19
K1 Mechanical ventilation
K1 Respiratory failure
AB Background The relative contribution of the diferent components of mechanical power to mortality is a subjectof debate and has not been studied in COVID-19. The aim of this study is to evaluate both the total and the rela‑tive impact of each of the components of mechanical power on mortality in a well-characterized cohort of patientswith COVID-19-induced acute respiratory failure undergoing invasive mechanical ventilation. This is a secondaryanalysis of the CIBERESUCICOVID project, a multicenter observational cohort study including ffty Spanish intensivecare units that included COVID-19 mechanically ventilated patients between February 2020 and December 2021. Weexamined the association between mechanical power and its components (elastic static, elastic dynamic, total elasticand resistive power) with 90-day mortality after adjusting for confounders in seven hundred ninety-nine patientswith COVID-19-induced respiratory failure undergoing invasive mechanical ventilation.Results At the initiation of mechanical ventilation, the PaO2/FiO2 ratio was 106 (78; 150), ventilatory ratio was 1.69(1.40; 2.05), and respiratory system compliance was 35.7 (29.2; 44.5) ml/cmH2O. Mechanical power at the initiationof mechanical ventilation was 24.3 (18.9; 29.6) J/min, showing no signifcant changes after three days. In multivariableregression analyses, mechanical power and its components were not associated with 90-day mortality at the startof mechanical ventilation. After three days, total elastic and elastic static power were associated with higher 90-daymortality, but this relationship was also found for positive end-expiratory pressure Conclusions Neither mechanical power nor its components were independently associated with mortality in COVID19-induced acute respiratory failure at the start of MV. Nevertheless, after three days, static elastic power and totalelastic power were associated with lower odds of survival. Positive end-expiratory pressure and plateau pressure,however, captured this risk in a similar manner.
PB Springer Nature
SN 2110-5820
YR 2025
FD 2025
LK http://hdl.handle.net/10498/36978
UL http://hdl.handle.net/10498/36978
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026