RT journal article
T1 Gold nanorod-assisted theranostic solution for nonvisible residual disease in bladder cancer
A1 Armanetti, Paolo
A1 Locatelli, Irene
A1 Venegoni, Chiara
A1 Alchera, Elisa
A1 Campanella, Beatrice
A1 Pederzoli, Filippo
A1 Maturi, Mirko
A1 Locatelli, Erica
A1 Tortorella, Silvia
A1 Curnis, Flavio
A1 Corti, Angelo
A1 Lucianò, Roberta
A1 Onor, Massimo
A1 Salonia, Andrea
A1 Montorsi, Francesco
A1 Moschini, Marco
A1 Popov, Viktor
A1 Jose, Jithin
A1 Comes Franchini, Mauro
A1 Hin Ooi, Ean
A1 Menichetti, Luca
A1 Alfano, Massimo
A2 Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica
AB Residual nonvisible bladder cancer after proper treatment caused by technological and therapeutic limitations is responsible for tumor relapse and progression. This study aimed to demonstrate the feasibility of a solution for simultaneous detection and treatment of bladder cancer lesions smaller than one millimeter. The α5β1 integrin was identified as a specific marker in 81% of human high-grade nonmuscle invasive bladder cancers and used as a target for the delivery of targeted gold nanorods (GNRs). In a preclinical model of orthotopic bladder cancer expressing the α5β1 integrin, the photoacoustic imaging of targeted GNRs visualized lesions smaller than one millimeter, and their irradiation with continuous laser was used to induce GNR-assisted hyperthermia. Necrosis of the tumor mass, improved survival, and computational modeling were applied to demonstrate the efficacy and safety of this solution. Our study highlights the potential of the GNR-assisted theranostic strategy as a complementary solution in clinical practice to reduce the risk of nonvisible residual bladder cancer after current treatment. Further validation through clinical studies will support the findings of the present study.
PB National Academy of Sciences of the United States of America
SN 1091-6490
YR 2024
FD 2024
LK http://hdl.handle.net/10498/37096
UL http://hdl.handle.net/10498/37096
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026