RT journal article
T1 Inorganic Polyphosphate: An Emerging Regulator of Neuronal Bioenergetics and Its Implications in Neuroprotection
A1 Montilla, M
A1 Pavas-Escobar, N
A1 Guatibonza-Arévalo, I. M.
A1 Múnera, A.
A1 Rivera-Melo, R. E.
A1 Ruiz Rodríguez, Félix Alejandro
A2 BiomedicinaBiotecnología y Salud Pública
K1 inorganic polyphosphate (polyP)
K1 mitochondrial bioenergetics
K1 neuroprotection
K1 neurodegenerative diseases
K1 therapeutic target
AB Inorganic polyphosphate (polyP) is an evolutionarily conserved polymer that has recently gained relevance in neuronal physiology and pathophysiology. Although its roles, such as mitochondrial bioenergetics, calcium homeostasis, and the oxidative stress response, for example, are increasingly recognized, its specific implications in neurological disorders remain underexplored. This review focuses on synthesizing the current knowledge of polyP in the context of central nervous system (CNS) diseases, highlighting how its involvement in key mitochondrial processes may influence neuronal survival and function. In particular, we examine recent evidence linking polyP to mechanisms relevant to neurodegeneration, such as the modulation of the mitochondrial permeability transition pore (mPTP), regulation of amyloid fibril formation, and oxidative stress responses. In addition, we analyze the emerging roles of polyP in inflammation and related cell signaling in CNS disorders. By organizing the existing data around the potential pathological and protective roles of polyP in the CNS, this review identifies it as a candidate of interest in the context of neurodegenerative disease mechanisms. We aim to clarify its relevance and stimulate future research on its molecular mechanisms and translational potential.
PB Multidisciplinary Digital Publishing Institute (MDPI)
SN 2218-273X
YR 2025
FD 2025
LK http://hdl.handle.net/10498/37853
UL http://hdl.handle.net/10498/37853
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026