RT journal article
T1 The differential burden of acute rhinovirus infections in children with underlying conditions
A1 Sánchez Codez, María Isabel
A1 Benavente Fernández, Isabel
A1 Moyer, Katherine
A1 Leber, Amy L.
A1 Ramilo, Octavio
A1 Mejias, Asuncion
A2 Materno-Infantil y Radiología
K1 Asthma
K1 Acute Disease
AB IntroductionRhinoviruses (RVs) are a well-known trigger of wheezing episodes in children with asthma. Their role in other pediatric chronic medical conditions is not fully known.MethodsPatients ≤21 years hospitalized or evaluated as outpatients with symptomatic RV infection were identified from 2011–2013. Patients were categorized based on the type of underlying disease and differences in clinical parameters, RV loads (CT values), viral, bacterial and fungal co-infections and clinical outcomes were compared between groups. Multivariable analyses were performed to identify the comorbidities associated with oxygen requirement, PICU admission, and prolonged hospitalization.ResultsOf 1,899 children identified, 77.7% (n = 1477) had an underlying comorbidity including asthma/atopy (36.8%), prematurity (7.7%), chronic respiratory diseases (6.4%), congenital heart disease (CHD, 3.2%), immunocompromised hosts (ICH; 1.4%) and others (22.2%). Prevalence of comorbidities increased with age (70%, infants vs 84%-87%, children >1 year; p < 0.0001). Median RV loads were intermediate-high (24–26 CT values), irrespective of the underlying disease. RV/viral co-detections were identified in 11% of ICH vs 20%- 30% in all other children whereas bacterial co-infections were identified in 2.9% of children. Multivariable models identified asthma/atopy, prematurity, CHD and bacterial co-infections consistently associated with all three clinical outcomes (p < 0.0001). Older age and higher RV loads were also associated with increased odds of PICU admission.ConclusionsThe prevalence of comorbidities was high in children with RV infections. Of those, asthma/atopy, prematurity and CHD were consistently associated with severe disease. Higher RV loads and bacterial co-infections, although infrequent, were also associated with worse clinical outcomes, suggesting the importance of defining clinical phenotypes for future targeted interventions.
SN 1932-6203
YR 2025
FD 2025-05-14
LK http://hdl.handle.net/10498/37856
UL http://hdl.handle.net/10498/37856
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026