RT journal article
T1 Impaired Glucose Tolerance and Altered Body Composition in Obese Young Adults: A Case–Control Study
A1 Mohamed Mohamed, Himan
A1 Pardo Moreno, Teresa
A1 Jiménez Palomares, Margarita
A1 Perez Andranaz, Bibiana
A1 Sánchez Lara, Encarnación María
A1 Vázquez Lara, María Dolores
A1 de la Mata Fernández, Mario
A1 García Morales, Victoria
A1 Ramos-Rodríguez, Juan José
A2 BiomedicinaBiotecnología y Salud Pública
K1 body mass index
K1 diabetes
K1 glucose intolerance
K1 insulin resistance
K1 obesity
AB Background/Objectives: To examine the association between body composition and glucose tolerance in young adults with normal weight, overweight, or obesity. Methods:This observational case–control study included 154 healthy individuals aged 18–25 years.Participants were categorized into three BMI-based groups and underwent anthropometricand body composition assessments using bioelectrical impedance. Glucose tolerance wasevaluated via oral glucose tolerance testing, with capillary blood samples collected atbaseline and at 30, 60, 90, and 120 min post load. Results: Compared to the normal-weightgroup, overweight and obese individuals exhibited significantly higher body weight, BMI,visceral and total fat percentages, and reduced muscle mass. Obese participants alsoshowed a significantly greater glucose area under the curve (AUC) and higher fasting andpost-load glucose levels. Visceral fat was positively correlated with metabolic impairment.These results indicate a progressive decline in glucose tolerance associated with increasingadiposity and reduced lean mass. Conclusions: Young adults with elevated BMI alreadydemonstrate marked alterations in body composition and impaired glucose tolerance, evenin the absence of overt metabolic disease. These findings underscore the importance ofthe early identification of at-risk individuals using simple, non-invasive tools. Preventivestrategies promoting healthy body composition in early adulthood may reduce the futurerisk of diabetes and its associated complications.
PB MDPI
SN 2227-9059
YR 2025
FD 2025-06-26
LK http://hdl.handle.net/10498/37873
UL http://hdl.handle.net/10498/37873
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026