RT journal article
T1 Definition of the Concept of Super-responders in Atopic Dermatitis: A Spanish Delphi Consensus
A1 Liñán-Barroso, Juan Manuel
A1 Hernández Rodríguez, Juan Carlos
A1 Ruiz Villaverde, Ricardo
A1 Galán Gutiérrez, Manuel
A1 Navarro-Triviño, Francisco
A1 Domínguez-Cruz, Javier
A1 Armario Hita, José Carlos
A1 Pereyra-Rodriguez, José-Juan
A2 Cirugía
A2 Medicina
K1 atopic dermatitis
K1 biological agents
K1 Delphi consensus
K1 Janus kinase inhibitors
AB A consensus study of experts was conducted to establish a definition of the concept of super-responders(SR) in atopic dermatitis (AD). The study employed aDelphi methodology based on 2 rounds to define theconcept of SR in AD, exploring the opinions of expertdermatologists in AD from across Spain regardinga series of statements developed after a systematicreview. Consensus was predefined as an agreementof ≥ 80% among all respondents. In the first round, 4statements reached consensus. In the second round,2 additional statements reached consensus. To illustrate these definitions, a set of practical cases wasprovided, and the level of agreement among expertswas evaluated. According to the agreed statements,time is important when defining the achievableresponse as SR. The concept of SR should associate arapid response (before week 16), include both symptom variables, such as the Eczema Area and SeverityIndex and Investigators Global Assessment (IGA) andpatient-reported outcomes, including pruritus or thePatient-Oriented Eczema Measure. This concept shouldbe associated with complete or nearly complete clearance of lesions (IGA 0–1), and with sustained responses over time (at week 52). Mild flares (IGA ≤2) mayoccur without varying according to the patient’s age.
PB MJS Publishing
SN 1651-2057
YR 2025
FD 2025-03
LK http://hdl.handle.net/10498/37955
UL http://hdl.handle.net/10498/37955
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026