RT journal article
T1 Successful treatment of renal cell carcinoma with paraneoplastic nephrotic syndrome: a case report
A1 Singh Singh, Arshdeep
A1 Naranjo Muñoz, Javier
A1 Alonso, Marta
A1 Villanego, Florentino
A1 Amaro, Jose Manuel
A1 Carrasco, Daniel
A1 Salvatierra, Cristina
A1 Mazuecos, Auxiliadora
A2 Cirugía
A2 Medicina
K1 membranous nephropathy
K1 nephrotic syndrome
K1 papillary renal cell carcinoma
K1 nephrectomy
K1 paraneoplastic nephropathy
K1 case report
AB The association of renal cell carcinoma (RCC) with paraneoplastic membranousnephropathy (MN) is rare. Accurate identification and treatment of the primarytumor can lead to resolution of nephrotic syndrome. We report the case ofa 72-year-old male was referred to Nephrology due to significant proteinuria(Urine albumin-creatinine ratio 14,000 mg/g) without clinical nephrotic syndrome.Imaging revealed a nodular lesion in the left kidney, compatible with the diagnosisof papillary renal neoplasia. A total left nephrectomy confirmed papillary RCC andMN. Post-surgery, renal function initially declined but stabilized, with proteinuriasignificantly reduced by the latest follow-up. Review of 20 cases of nephroticsyndrome associated with RCC revealed that MN was the most frequent underlyingnephrosis. MN is frequently associated with solid tumors, but its link with RCC isuncommon. In our review, clear cell carcinoma (CCC) was the most prevalentRCC subtype linked with MN. Early cancer screening in MN patients can uncoveroccult malignancies, facilitating timely treatment. RCC-associated MN is rare butshould be considered in patients presenting with nephrotic syndrome. Surgicalresection of the RCC can lead to resolution of the associated nephropathy. Thiscase underscores the importance of thorough cancer screening in patients withunexplained nephrotic syndrome.
PB Frontiers
SN 2296-858X
YR 2025
FD 2025-03
LK http://hdl.handle.net/10498/37957
UL http://hdl.handle.net/10498/37957
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026