RT journal article T1 Analysis of the Effect of Pupil Size and Corneal Aberration on the Optical Performance of Premium Intraocular Lenses A1 Miret, Juan J. A1 Camps, Vicente J. A1 García, Celia A1 Caballero, Maria T. A1 Sempere-Molina, Antonio A1 González Leal, Juan María A2 Física de la Materia Condensada K1 cataract K1 Lasik surgery K1 premium IOLs K1 refractive surgery AB Background/Objectives: To assess the optical performance of two refractive premium IOLs across pupil sizes and values of corneal spherical aberration (SA). Methods: Two refractive IOLs were evaluated in this study: Tecnis Eyhance and Mini Well. The surface profiles were obtained to calculate the through-object MTF (TO MTF) curves and simulate optotype images. Entrance pupil sizes ranging from 2 to 5.5 and three corneal models were analyzed in the simulation: an average population aberrated cornea, an aberration-free cornea and a post-Lasik myopic cornea. Results: For Model 1 and pupil sizes between 3.0 and 3.5 mm, Mini Well provided acceptable visual quality from far to near distances, whereas Eyhance struggled to maintain visual quality at distances closer than intermediate. For patients with lower-than-normal corneal SA (i.e., more prolate corneas, such as post-hyperopic LASIK) both IOLs exhibited a hyperopic shift in far focus. Conversely, for patients with higher-than-normal corneal SA (i.e., more oblate corneas, such as post-myopic LASIK), the shift occurred in the myopic direction. Despite the implementation of an optimized IOL power to circumvent any shift, the TO MTF nevertheless reflected the interaction between corneal and IOL SA. Furthermore, the Mini Well demonstrated increased tolerance to less negative SA values, while Eyhance exhibited behavior consistent with a monofocal lens for more positive SA values. Conclusions: Surgeons should consider each patient’s corneal asphericity and typical pupil diameter when selecting and calculating the power of the premium IOLs studied, particularly in patients with a history of refractive surgery. PB Multidisciplinary Digital Publishing Institute (MDPI) SN 2077-0383 YR 2025 FD 2025-07 LK http://hdl.handle.net/10498/38017 UL http://hdl.handle.net/10498/38017 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 10-may-2026