RT journal article
T1 Fast synthesis of biocompatible iron oxide nanoparticles via a microwave-assisted Schikorr reaction: Phase-director influence of iron glycinate complexes
A1 Santana Otero, Antonio
A1 Frade González, José Carlos
A1 Ramírez del Solar, Milagrosa
A1 Ortega Ponce, Daniel
A2 Física de la Materia Condensada
K1 Microwave synthesis
K1 Magnetic nanoparticles
K1 GlycineIron oxides
K1 Theranostics
AB In this study, we present a rapid method for synthesizing iron oxide nanoparticles using a microwave-assisted Schikorr reaction. We propose the use of glycine to inhibit the formation of parasitic phases even from the initial mixture of reagents. In addition to forming the nanoparticles, the method allows for the preparation of their surface for subsequent bioconjugation using a combined glucose-fructose and glycine coating at moderately low temperatures. We demonstrate that the fast formation of iron glycinates prevents the appearance of unintended compounds, which is particularly useful for controlling the Schikorr reaction and avoiding premature reactions during precursor mixing. Glycine also acts as a surfactant, limiting the growth of unwanted clusters and expanding the bioconjugation capabilities of the nanoparticles, favoring their application in theranostics. Finally, cell viability tests at different nanoparticle concentrations do not reveal significant cytotoxicity, strengthening the evidence for biocompatibility.
PB Elsevier
SN 0925-8388
YR 2025
FD 2025-06-19
LK http://hdl.handle.net/10498/38026
UL http://hdl.handle.net/10498/38026
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026