RT journal article
T1 Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
A1 Martín Carmona, Jésica
A1 Corma Gómez, Anaïs
A1 Moyano, Jose M.
A1 Téllez Pérez, Francisco de Paula
A1 Arenga Barrios, Dolores
A1 Serrano-Fuentes, Miriam
A1 Morano Vázquez, Aitana Carla
A1 Corona Mata, Diana
A1 Navarrete Lorite, Miguel Nicolás
A1 Vera-Méndez, Francisco Jesús
A1 Barroso, Isabel
A1 Palacios, Rosario
A1 de los Santos, Ignacio
A1 Belinchón, Olga
A1 Galera, Carlos
A1 Imaz, Arkaitz
A1 Merino, Dolores
A1 Reus Bañuls, Sergio Javier
A1 Galindo, Maria Jose
A1 López-Zuñiga, Miguel Ángel
A1 Pineda, Juan A.
A1 Macías, Juan
A2 Cirugía
A2 Medicina
K1 HIV
K1 Hepatitis C
K1 Sustained viral response
K1 Transient elastography
K1 Liver stiffness
AB Background: After sustained virological response (SVR), liver stiffness (LS) usually decreases. However, information related to the impact of HIV co-infection in patients with advanced fibrosis is scarce. The aim was to analyze the impact of HIV co-infection on the LS dynamics after HCV cure. Methods: Prospective study conducted in the GEHEP-011 multicenter cohort (initiated in October 2011–November 2023, ID NCT04460157), including patients with chronic HCV infection, with or without HIV co-infection, fulfilling: 1) SVR with direct-acting antivirals; 2) pre-treatment LS ≥ 9.5 kPa; 3) available measurement of LS at SVR. Pre-treatment, SVR and annual post-treatment LS were assessed. The primary outcome was time to LS normalization achievement (≤7.2 kPa) in two consecutive examinations. Findings: 1138 patients were included, 678 (60%) of whom were living with HIV (PLWH). The median time between the first to the last measure was 35 (17–69) months. In total, 390 [34% (95% confidence interval, 31%–37%)] patients achieved LS normalization, 169 [37% (CI 95%, 34%–43%)] individuals with HCV mono-infection vs. 221 [32% (CI 95%, 29%–36%)] PLWH achieved LS normalization (p = 0.003). The propensity score (PS) for HIV infection was calculated. In a multivariate model for competing risks (death was the competing event) adjusted for HIV, PS and diabetes, HIV infection was associated with a lower probability of achieving normalization [sHR = 0.82 (95% CI, 0.67–1.00), p = 0.045]. Matching by closer PS was performed. In the resultant subset, the probability of achieving LS normalization was again lower in PLWH [sHR = 0.76 (0.56–0.97), p < 0.001]. Interpretation: After SVR, the probability of reaching LS normalization is significantly lower in PLWH. This could have implications on the development of long-term clinical events. Funding: Project PI19/01443, ERDF/ESF “Investing in your future”, GLD21_00096, GEHEP-011 project, B-0061-2021, JR24/00044, A1-0060-2021, CM23/00255, CM22/00176.
PB Public Library of Science
SN 2589-5370
YR 2025
FD 2025-05-12
LK http://hdl.handle.net/10498/38038
UL http://hdl.handle.net/10498/38038
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026