RT journal article
T1 A global cross-sectional survey on neonatal analgosedation: unveiling global trends and challenges through latent class analysis
A1 Arribas, Cristina
A1 Cavallaro, Giacomo
A1 Decembrino, Nunzia
A1 González Caballero, Juan Luis
A1 Lagares Franco, Carolina María
A1 Raffaeli, Genny
A1 Smits, Anne
A1 Simons, Sinno P.H.
A1 Villamor, Eduardo
A1 Allegaert, Karel
A1 Garrido, Felipe
A2 Estadística e Investigación Operativa
A2 Materno-Infantil y Radiología
K1 Newborn
K1 Analgosedation
K1 Tracheal intubation
K1 Latent class analysis
K1 Sociodemographic index
AB Purpose: This study aims to analyze global prescribing patterns for analgosedation in neonates during four critical care scenarios. The research explores existing patterns, their association with geographic and sociodemographic index (SDI), and adherence to evidence-based practices. Methods: Data from a 2024 global survey of 924 responses to 28 questions were analyzed, focusing on four items for their high variability: premedication in intubation (Q17), sedation in preterm (Q19) and full-term newborns (Q23), and perinatal asphyxia (Q26). Latent class analysis (LCA) classified neonatal intensive care unit (NICU) prescriptions into patterns, assigning participants to the most likely class. Demographic variables, including geographic region and SDI, were compared using chi-square tests to assess associations. Results: Three distinct prescribing patterns emerged for each scenario. In premedication during intubation, Europe and North America predominantly used Class 1, adhering to guidelines with fentanyl, atropine, and muscle relaxants. In contrast, Class 2, standard in Asia and Latin America-Caribbean, primarily utilized fentanyl and midazolam, with rare use of atropine and muscle relaxants. For analgosedation in newborns, higher-SDI NICUs favored fentanyl, while lower-SDI NICUs preferred midazolam or morphine combinations. In perinatal asphyxia cases, fentanyl was the leading choice in Class 3, especially in Europe. Dexmedetomidine use was limited, primarily appearing in Class 1 NICUs. Conclusion: The study highlights substantial regional variability in neonatal analgosedation, influenced by SDI and geography. Despite established guidelines, gaps in evidence-based implementation persist. These findings underscore the need for global standardization of neonatal care protocols and further research on the long-term safety of midazolam and dexmedetomidine.
PB Springer
SN 1432-1076
YR 2025
FD 2025-03
LK http://hdl.handle.net/10498/38044
UL http://hdl.handle.net/10498/38044
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026