RT journal article
T1 Efecto de la administración de diferentes formas de vitamina D en la presión arterial y rigidez aórticas, y su implicación en la reducción de la albuminuria en la enfermedad renal crónica
A1 Martin Romero, Almudena
A1 Perelló Martínez, Jary
A1 Hidalgo Santiago, Juan Carlos
A1 Michán Doña, Alfredo
A1 López Sáez, José Juan Bosco
A1 Gómez Fernández, Pablo
A2 Medicina
K1 Vitamina D
K1 Paricalcitol
K1 Rigidez arterial
K1 Albuminuria
K1 Chronic kidney
K1 disease
K1 Vitamin D
K1 Arterial stiffness
AB Background and objectives: Vitamin D(vitD) participates in phospho-calcium metabolism and exerts multiple pleiotropic effects. There is tissue 1-ct (OH)ase that converts 25-OH cholecalci-ferol (25 (OH) D) in calcitriol that exerts autocrine and paracrine effects. 25 (OH)D deficiency could limit these tissue effects of vitD. The administration of nutritional vitD and the activator of the vitD receptor, paricalcitol, may promote beneficial effects on vascular and renal function. The objective of this work was to study in subjects with chronic kidney disease (CKD) the effect that the administration of different forms of vitD has on arterial function and albuminuria, and the possible relationship between the modifications of these variables. Patients and methods: We studied in 97 patients with CKD stages 3-4 the effect of the adminis-tration of cholecalciferol (group 2; n: 35) and paricalcitol (n: 31; group 3) on parameters derived from brachial blood pressure, aortic blood pressure and on aortic stiffness studied using carotid -femoral pulse velocity (Vpc-f), and on albuminuria. A group of patients with stages 3-4 CKD who did not receive vitD therapy served as a control group (n: 31; group 1). All parameters were studied at baseline and after the follow-up period which was 7 +/- 2 months. Results: In the baseline phase, no differences were observed between the groups in brachial systolic blood pressure (bSBP), central systolic blood pressure (SBP), brachial pulse pressure (bPP), and central pulse pressure (pCP) or in aortic stiffness that was increased in all groups with a baseline Vpc-f value of 10.5 (9.2-12.1) m/sec. The baseline albuminuria value in the grouped patients was 229 (43-876) mg / g (median (interquartile range)), with no differences between the groups.
PB Sociedad Española de Arteriosclerosis (2022) Vol. 34, pp. 311-321
SN 0214-9168
YR 2022
FD 2022
LK http://hdl.handle.net/10498/38233
UL http://hdl.handle.net/10498/38233
LA spa
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026