RT journal article
T1 Clinical Characteristics and Impact of May-Thurner Syndrome in Patients With Proximal Deep Vein Thrombosis: Insights From the RIETE Registry
A1 Varona, José F.
A1 Ochoa Chaar, Cassius Iyad
A1 Pedrajas, José María
A1 Barillari, Giovanni
A1 Gil-Díaz, Aída
A1 Montenegro Arenas, Ana Cristina
A1 López Sáez, José Juan Bosco
A1 Bok Yoo, Hugo Hyung
A1 Riera Mestre, Antoni
A1 Monreal, Manuel
A2 Cirugía
A2 Medicina
K1 venous thromboembolism
K1 proximal deep vein thrombosis
K1 May-Thurner syndrome
K1 endovascular therapy
K1 anticoagulation
AB May-Thurner syndrome (MTS) is an anatomical variant involving compression of the left iliac vein, predisposing to proximaldeep vein thrombosis (DVT). Despite its clinical significance, population-level data remain limited. Using the RIETE (RegistroInformatizado Enfermedad Trombo-Embólica) registry (2009-2024), we analyzed proximal DVT patients who underwentadvanced imaging (CT-venography, contrast-venography, or MRI). Among 2872 patients with advanced imaging-confirmedproximal DVT, 124 (4.3%) had MTS. MTS patients were more likely to be female (78% vs 52%), younger (mean age 42 vs62years), and to present with left-sided DVT (92% vs 46%). They had fewer comorbidities, but greater exposure to estrogenor pregnancy. Endovascular therapy was more frequently used in MTS patients (44% vs 3.5%), who also received longer mediananticoagulation (365 vs 164days). Despite this, MTS patients had a significantly higher rate of recurrent DVT (rate ratio: 2.37;95% CI 1.09-4.70). Multivariable analysis confirmed MTS as an independent predictor of recurrent DVT (adjusted hazardratio: 2.26; 95% CI: 1.02-5.01). Major bleeding was non-significantly less frequent (rate ratio: 0.42; 95% CI: 0.13-1.04), thoughretroperitoneal bleeding was more common. MTS is underdiagnosed, has distinct clinical features and is associated withincreased DVT recurrence despite aggressive therapy. Improved recognition and tailored management strategies are needed.
PB SAGE PUBLICATIONS
SN 1940-1574
YR 2025
FD 2025-11
LK http://hdl.handle.net/10498/38238
UL http://hdl.handle.net/10498/38238
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026