RT journal article T1 Bioaccumulation kinetics of copper in Ruditapes philippinarum exposed to increasing, continuous and pulsed exposure: Implications for growth A1 Santana, Ligia A1 Blasco, Julian A1 Abessa, Denis A1 Campana, Olivia A2 Química Física AB Metal bioaccumulation and toxicity to aquatic organisms depends on factors such as magnitude, duration and frequency of the exposure. The type of the exposure affects the toxicokinetic processes in the organisms. In this study, we carried out 30-day toxicity tests on juveniles of Ruditapes philippinarum exposed to increasing, continuous and pulsed exposure. Organisms were exposed to copper-spiked sediments followed by a 10-day recovery period. We assessed the interaction between the kinetics of subcellular copper partitioning and the growth response. Results showed that the growth rate of the bivalve was inversely correlated to the bioaccumulation rate and that sublethal copper concentrations stimulated the detoxification mechanisms inside the organism regardless the type of the exposure. However, a large stimulatory effect on growth was observed during the recovery period, associated with significant negative accumulation rate values and dependent on the type of antecedent exposure. This suggested that on individual and short-term basis pulsed exposures have a more adverse effect compared to increasing or continuous exposure scenarios. PB Elsevier SN 1879-1026 YR 2017 FD 2017 LK http://hdl.handle.net/10498/38320 UL http://hdl.handle.net/10498/38320 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 09-nov-2026