RT journal article T1 Circuit resistance training improved endothelial dysfunction in obese aged women T2 Mejora de la disfunción endotelial en mujeres mayores obesas mediante entrenamiento de fuerza A1 Rosety Rodríguez, Ignacio A1 Pery Bohórquez, María Teresa A1 Rosety Rodriguez, Jesús A1 García Gómez, Natalia A1 Rodríguez Pareja, María Antonia A1 Brenes Martín, Francisco A1 Díaz Ordóñez, Antonio Jesús A1 Rosety Rodríguez, Manuel A1 Ordóñez Muñoz, Francisco Javier A1 Rosety Rodríguez, Miguel Ángel A2 Anatomía y Embriología Humana A2 Didáctica de la Educación FísicaPlástica y Musical A2 Medicina K1 Aged K1 Endothelin-1 K1 Endothelium disorder K1 Intercellular adhesion molecule-1 K1 Resistance training K1 Vascular cell adhesion molecule-1 AB Introduction: It is widely accepted that obesity is associated with endothelial dysfunction. In a recent paper, we have also found circuit resistance training may reduce visceral fat in obese aged women. Accordingly, the current study was conducted to ascertain the effects of circuit resistance training on markers of endothelial dysfunction in this population group. Methods: In the present interventional study, a total of 48 obese aged women were recruited from the community. Twenty-four of them were randomly assigned to perform a 12-week resistance circuit training programme, 3-days per week. This training was circularly performed in 6 stations: arm curl, leg extension, seated row, leg curl, triceps extension and leg press. The Jamar handgrip electronic dynamometer was used to assess maximal handgrip strength of the dominant hand. Lastly, serum samples were analysed using an immunoassay (ELISA) for endothelin-1, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Results: When compared to baseline, resistance training significantly reduced serum levels of endothelin-1 (2.28 ± 0.7 vs. 1.98 ± 1.1 pg/ml; p = 0.019; d = 0.67) and ICAM-1 (290 ± 69 vs. 255 ± 76 ng/ml; p = 0.004; d = 0.92) in the experimental group. No significant changes in any of the tested outcomes were found in the control group. Conclusion: A short-term circuit resistance program improved endothelial dysfunction in aged obese women. Further studies on this topic are still required to consolidate this approach in clinical application. PB Grupo Aula Medica S.A. SN 0212-1611 YR 2016 FD 2016 LK http://hdl.handle.net/10498/38369 UL http://hdl.handle.net/10498/38369 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 06-nov-2026